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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
GLP compliance:
yes (incl. QA statement)
Test type:
acute toxic class method
Limit test:
yes

Test material

1
Chemical structure
Reference substance name:
(E)-(4-methoxy-2,3,6-trimethylphenyl)-3-buten-2-one
EC Number:
263-760-4
EC Name:
(E)-(4-methoxy-2,3,6-trimethylphenyl)-3-buten-2-one
Cas Number:
62924-31-6
Molecular formula:
C14H18O2
IUPAC Name:
1-(4-methoxy-2,3,6-trimethylphenyl)but-3-en-2-one
Test material form:
solid: particulate/powder

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
female

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
no mortality.
Clinical signs:
other: A decrease in spontaneous activity and myosis were noted during the first hours of the test. The animals recovered a normal behaviour between 4 and 24 hrs post-dose.
Gross pathology:
No treatment related changes.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 of the test item is higher than 2000 mg/kg bw by oral route in the rat.