(E)-(4-methoxy-2,3,6-trimethylphenyl)-3-buten-2-one

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2001

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Limit test:

yes

Test material

Test material information

1

Reference substance name:

(E)-(4-methoxy-2,3,6-trimethylphenyl)-3-buten-2-one

EC Number:

263-760-4

EC Name:

(E)-(4-methoxy-2,3,6-trimethylphenyl)-3-buten-2-one

Cas Number:

62924-31-6

Molecular formula:

C14H18O2

IUPAC Name:

1-(4-methoxy-2,3,6-trimethylphenyl)but-3-en-2-one

Test material form:

solid: particulate/powder

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

female

Administration / exposure

Route of administration:

oral: unspecified

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

no mortality.

Clinical signs:

other: A decrease in spontaneous activity and myosis were noted during the first hours of the test. The animals recovered a normal behaviour between 4 and 24 hrs post-dose.

Gross pathology:

No treatment related changes.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The LD50 of the test item is higher than 2000 mg/kg bw by oral route in the rat.