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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
04 December, 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Test substance is adequately specified. Therefore full validation applies.
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
Commission Regulation (EC) No 761/2009 of 23. July 2009, published on 24. Aug. 2009
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
Remarks:
inspected on 13 and 14 October 2014 / signed on 08 April 2015
Type of method:
static method
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
717 Pa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
985 Pa

The calculation results are presented in the following table:

Table 4.6/1: Measurement Values

1. Determination

increasing temperature

2. Determination

decreasing temperature

Temp. in °C

Pressure in hPa

Temp. in °C

Pressure in hPa

20.0

8.1

48.1

34.3

28.9

14.0

38.9

28.4

38.0

24.4

30.1

12.9

47.0

35.0

21.1

7.4

56.1

48.3

16.0

4.3

Table 4.6/2: Calculated values for 1/T and log P

n                  

Temperature T (°C)

Pressure P (hPa)

Temperature T (K)

1/T (1/K)

log P

log Pa

1

20.0

8.1

293.15

0.00341122

2.9085

2

28.9

14.0

302.05

0.00331071

3.1461

3

38.0

24.4

311.15

0.00321388

3.3874

4

47.0

35.0

320.15

0.00312354

3.5441

5

56.1

48.3

329.25

0.00303721

3.6839

6

48.1

34.3

321.25

0.00311284

3.5353

7

38.9

28.4

312.05

0.00320461

3.4533

8

30.1

12.9

303.25

0.00329761

3.1106

9

21.1

7.4

294.25

0.00339847

2.8692

10

16.0

4.3

289.15

0.00345841

2.6335

linear regression :

y = -2407.436102 x + 11.06785182

r² = 0.965330749  (> 0.95)

Using the equations below, vapour pressures at ambient temperature were calculated.

P(20 °C) = 10B * (1/293.15) + A 

P(25 °C) = 10B * (1/298.15) + A

Table 4.6/3: Calculated Values for vapour pressure

Parameter

Value

Vapour Pressure (20 °C)

717 Pa

Vapour Pressure (25 °C)

985 Pa

 

The vapour pressure of the test item was measured using the static method as described in EU method A.4. Ten pairs temperature/vapour pressure were used to calculate a regression from which vapour pressure at ambient temperature could be estimated.

From the measured values, the vapour pressure of the test item was calculated as 717 Pa at 20.0 °C and 985 Pa at 25 °C. The values of the heating and cooling down phase showed good correspondence.

Therefore, the result of the study is considered valid.

Conclusions:
The vapour pressure of the test item was calculated as 717 Pa at 20.0 °C and 985 Pa at 25 °C (interpolation).
These values represent the component with the highest vapour pressure.
Executive summary:

The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline, static method. Ten pairs temperature/vapour pressure were used to calculate a regression in a temperature range of 16.0 – 56.1 °C, from which vapour pressure at ambient temperature could be estimated.

From the measured values, the vapour pressure of the test item was calculated as 717 Pa at 20.0 °C and 985 Pa at 25 °C.

These values represent the component with the highest vapour pressure.

Description of key information

The vapour pressure of the test item was calculated as 717 Pa at 20.0 °C and 985 Pa at 25 °C (interpolation).

These values represent the component with the highest vapour pressure.

Key value for chemical safety assessment

Vapour pressure:
985 Pa
at the temperature of:
25 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study, and the result is retained as key data for purpose of CSA.

The vapour pressure of the test item was calculated as 717 Pa at 20.0 °C and 985 Pa at 25 °C.

Note that the result obtained on this kind of substance should be largely influence by small amounts of volatile constituents and these values don't represent the major part of the substance. Therefore the result should be considered with caution when used for subsequent assessment (worst case).