Registration Dossier
Registration Dossier
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EC number: 204-588-1 | CAS number: 122-98-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP non-guideline study, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- According to BASF-internal method: Two cats exposed orally to preparations of the test substance. Documentation of the clinical signs was performed over the 30 hour study period. Necropsy was performed at the end of the study.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-anilinoethanol
- EC Number:
- 204-588-1
- EC Name:
- 2-anilinoethanol
- Cas Number:
- 122-98-5
- Molecular formula:
- C8H11NO
- IUPAC Name:
- 2-(phenylamino)ethan-1-ol
- Details on test material:
- - Name of the test substance used in the study report: Mono-oxaethylanilin
- Physical state: liquid
Constituent 1
Test animals
- Species:
- cat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 4.15 kg and 2.84 kg
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Test concentration used was 1% (v/v); aqueous solution
- Doses:
- 0.05 mL/kg
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 30 hours
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, other: clinical chemistry for methemoglobin
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 0.05 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Corresponding to 55 mg/kg bw
- Mortality:
- No mortality observed.
- Clinical signs:
- other: Heavy breathing, cyanosis, salivation, apathy, and balance disorders were observed. After 1 day, no symptoms were observed.
- Gross pathology:
- Blackish brown blood, brown coloured lungs, pulmonary oedema, liver with yellow parts, and a bladder filled with brownish yellow urine were observed.
- Other findings:
- Methemoglobin up to 69%
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
