Registration Dossier
Registration Dossier
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EC number: 204-588-1 | CAS number: 122-98-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data published in peer reviewed literature, restrictions in design and/or reporting but contributing to a weight of evidence assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth H.F. et al.
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J., 23, 95-107
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Penetration of rabbit skin is estimated by a technique closely skin to the one-day cuff method fo Draize and associates, using group of four male albino New Zealand rabbits. Based upon mortalities during a 14-day observation period the most probable LD50 and is fiducial range are estimated by the method of Thompson.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-anilinoethanol
- EC Number:
- 204-588-1
- EC Name:
- 2-anilinoethanol
- Cas Number:
- 122-98-5
- Molecular formula:
- C8H11NO
- IUPAC Name:
- 2-(phenylamino)ethan-1-ol
- Details on test material:
- - Name of test material (as cited in article): N-(2-Hydroxyethyl)phenylamine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 - 3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: clipped trunk
- Type of wrap if used: impervious plastic film
REMOVAL OF TEST SUBSTANCE
- No washing
- Time after start of exposure: 24 hours
The animals are immobilized during the exposure period. - Duration of exposure:
- 24 hours
- No. of animals per sex per dose:
- 4 males per group
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- Most probable LD50 value and its fiducial range (± 1.96 SD) are estimated by the method of Thompson using the Tables of Weil
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.063 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- 0.043 - 0.094
Applicant's summary and conclusion
- Interpretation of results:
- highly toxic
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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