1,4-naphthoquinone

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Study included as a supporting study to support Classification and Labelling and is not considered as reliable for REACH purposes as the full experimental report is not available.

Data source

Reference

Reference Type:

review article or handbook

Title:

1,4-Naphthoquinone - BUA Report 211 (October 1998)

Author:

GDCh-Advisory Committee on Existing Chemicals (BUA)

Year:

1998

Bibliographic source:

S.Hirzel Verlag Stuttgart; Wissenschaftliche Verlags-Gesellschaft Stuttgart, 2000 , ISBN3-7776-1064-X

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

1981

Deviations:

not specified

GLP compliance:

yes

Test type:

other: Not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

1,4-naphthoquinone

EC Number:

204-977-6

EC Name:

1,4-naphthoquinone

Cas Number:

130-15-4

Molecular formula:

C10H6O2

IUPAC Name:

1,4-naphthoquinone

Test material form:

solid

Specific details on test material used for the study:

Purity detailed as 95.8%

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

whole body

Vehicle:

air

Mass median aerodynamic diameter (MMAD):

>= 3.8 - <= 4.2 µm

Remark on MMAD/GSD:

Respirable fraction 64.4 to 69.8% (< 6 µm)

Analytical verification of test atmosphere concentrations:

yes

Duration of exposure:

4 h

Remarks on duration:

4 hours exposure followed by a 14 day observation period

Concentrations:

0.065, 0.036 and 0.021 mg/L in air.

No. of animals per sex per dose:

5 males and 5 females per group

Control animals:

yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

0.046 mg/L air

Based on:

test mat.

Exp. duration:

4 h

Mortality:

Mortality occured but the exact numbers are not specified.

Clinical signs:

other: During exposure signs of irritation of the eyes and respiratory tract were observed in all groups which also continued into the observation period. Clouding of the cornea developed in 5/17 surviving animals in the intermediate and low concentration groups

Body weight:

Body weight values declined for up to 5 days after exposure and the weight of the surviving rats did not reach that of the control animals again by the end of the observation period, except in the low concentration group.

Gross pathology:

Post-mortems revealed congestion of the lungs, which were mottled in places, and histological examination showed vacuolisation and necrotic foci in the liver cells. The kidneys showed tubular basophilia and dilation of the tubular lumen.

Other findings:

Food and water consumption was decreased for up to 7 and 5 days after exposure, respectively.

Applicant's summary and conclusion

Interpretation of results:

Category 1 based on GHS criteria

Conclusions:

The LC50 value obtained under the experimental conditions described was 0.046 mg/L combined for both males and females.