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Key value for chemical safety assessment

Toxicity to reproduction: other studies

Description of key information

In a rat reproduction toxicity study (OECD 421/422), oral administration of DBU at doses of 15, 50 and 150 mg / kg body weight showed signs of parental toxicity at the highest dose ( 150 mg / kg of body weight). The effects were local and limited to the stomach, and were probably caused by the strong alkaline corrosiveness of the DBU. No signs of reproductive and developmental toxicity were observed for the three doses administered. The NOAEL for parental toxicity was then set at 50 mg / kg of body weight, while the NOAEL for reproductive and developmental toxicity was established to be 150 mg / kg body weight.

Justification for classification or non-classification

All effects were local and limited to the stomach, and can be attributed to the strong alkaline corrosiveness of the DBU. No other toxicologically significant change was observed in the treated animals.

No classification is proposed based on available data.

Bibliographic source:

REACH Registration Dossier, 1,8-diazabicyclo[5.4.0]undec-7-ene

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