Registration Dossier

Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Substances with an extreme pH (≤ 2 or ≥ 11.5) may represent a potential corrosion hazard for the skin (DBU = pH 12.6). The corrosive potential of DBU was also evaluated using a membrane-barrier test method (Corrositex assay).

The test determined an average crossing time of 20 minutes (calculated on 6 replications) and a substance pH of 14.

Scientifically not necessary study. Substances with an extreme pH (≤ 2 or ≥ 11.5) may produce severe ocular lesions (DBU = pH 12.6).

In addition, corrosive substances for the skin are considered to be capable of causing serious eye damage.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irreversible damage)

Additional information

Bibliographic source:

REACH Registration Dossier, 1,8-diazabicyclo[5.4.0]undec-7-ene

Justification for classification or non-classification

The substance is classified as causes severe skin burns and eye damage. (CLP Regulation - category 1B)

The substance is classified as causes serious eye damage. (CLP Regulation - category 1)

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