Registration Dossier
Registration Dossier
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EC number: 307-988-5 | CAS number: 97808-67-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- An ocular irritation study of test material.
- Author:
- GREIM H et. al.,
- Year:
- 1 994
- Bibliographic source:
- Chemosphere, 1994.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the eye irritation potential of the test substance
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-(ethylamino)toluene-4-sulphonic acid
- EC Number:
- 202-664-9
- EC Name:
- 2-(ethylamino)toluene-4-sulphonic acid
- Cas Number:
- 98-40-8
- Molecular formula:
- C9H13NO3S
- IUPAC Name:
- 3-(ethylamino)-4-methylbenzenesulfonic acid
- Test material form:
- solid
- Details on test material:
- Name of the test chemical:
Molecular formula:C9H13NO3S
Molecular Weight:215.272 g/mol
Physical State: Solid
InChI: 1S/C9H13NO3S/c1-3-10-9-6-8(14(11,12)13)5-4-7(9)2/h4-6,10H,3H2,1-2H3,(H,11,12,13)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- no data available
- Duration of treatment / exposure:
- no data available
- Observation period (in vivo):
- no data available
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- no data available
- Details on study design:
- no data available
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: no data available
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- no irritation observed
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- The test chemical was observed to be not irritating to eyes.
- Executive summary:
An ocular irritation test was conducted on rabbits bl to determine the eye irritation potential of test chemical chemical.
The chemical did not induce any ocular lesions during the study.
Hence the test chemical was considered as not irritating.
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