Registration Dossier
Registration Dossier
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EC number: 946-901-0 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Based on a weight of evidence approach, the acute toxicity oral of this UVCB substance can be estimated using adequate toxicity data of major constituents, greater than 1% in the mixture.
7 constituents were considered, representing 87% of the mixture. But 4 constituents have an available LD50 oral.These data are summarized in the table below.
The acute toxicity oral was estimated using the following additivity formula, as recommended in the Regulation (EC) No 1272/2008 (CLP) part 3.1.3.6.2.3.:
100-(∑ Ci unkown if > 10 %) / ETA mix = ∑ (Ci / ETAi)Where,Ci = concentration of component i (weight percentage); i = the individual ingredient from 1 to n ; n = the number of ingredients ; ATE i = Acute Toxicity Estimate of ingredient i.
Test material
- Reference substance name:
- Reaction mass of 2-isopropenyl-5-methylhex-4-en-1-ol and 2-isopropenyl-5-methylhex-4-enyl acetate and DL-borneol and caryophyllene and linalool and linalyl acetate and p-menth-1-en-4-ol
- EC Number:
- 946-901-0
- Molecular formula:
- not relevant
- IUPAC Name:
- Reaction mass of 2-isopropenyl-5-methylhex-4-en-1-ol and 2-isopropenyl-5-methylhex-4-enyl acetate and DL-borneol and caryophyllene and linalool and linalyl acetate and p-menth-1-en-4-ol
Constituent 1
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- approximate LD50
- Effect level:
- ca. 6 014 mg/kg bw
- Based on:
- other: calculation according to additivity formula of CLP regulation section 3.1.3.6.2.3.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The lavandin oil heavy fraction is not classified according to CLP criteria and GHS criteria.
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