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Short-term toxicity to aquatic invertebrates

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Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
Qualifier:
according to guideline
Guideline:
other: ECOSAR
Version / remarks:
1.11
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
0.681 mg/L
Validity criteria fulfilled:
not specified
Conclusions:
LC50 of daphnia is 0.681 mg/L for acetate lavandulyle.
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
Qualifier:
according to guideline
Guideline:
other: ECOSAR
Version / remarks:
1.11
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
0.82 mg/L
Validity criteria fulfilled:
not specified
Conclusions:
LC50 of daphnia is 0.820 mg/L for acetate linalyle.
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
Qualifier:
according to guideline
Guideline:
other: ECOSAR
Version / remarks:
1.11
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
13.38 mg/L
Validity criteria fulfilled:
not specified
Conclusions:
LC50 of daphnia is 13.380 mg/L for borneol.
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
Qualifier:
according to guideline
Guideline:
other: ECOSAR
Version / remarks:
1.11
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
0.019 mg/L
Validity criteria fulfilled:
not specified
Conclusions:
LC50 of daphnia is 0.019 mg/L for caryophyllene.
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
Qualifier:
according to guideline
Guideline:
other: ECOSAR
Version / remarks:
1.11
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
3.903 mg/L
Validity criteria fulfilled:
not specified
Conclusions:
LC50 of daphnia is 3.903 mg/L for lavandulol.
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
Qualifier:
according to guideline
Guideline:
other: ECOSAR
Version / remarks:
1.11
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
4.698 mg/L
Validity criteria fulfilled:
not specified
Conclusions:
LC50 of daphnia is 4.698 mg/L for linalol.

Description of key information

Based on a weight of evidence approach, the acute toxicity of lavandin oil heavy fraction to aquatic invertebrates (daphnia) can be estimated using adequate toxicity data of major constituents, greater than 1% in the mixture. Six constituents were considered representing more than 85% of the UVCB substance.These data are summarized in the table below:

Constituent names  CAS nr LC50 daphnia 48h (mg/L) source
acetate linalyle (67%) 115 -95 -7 0.82 ECOSAR V1.11
borneol (5%)  507 -70 -0 13.38  ECOSAR V1.11
acetate lavandulyle (5%) 25905-14-0 0.681  ECOSAR V1.11
linalol (3%) 78-70-6 4.698  ECOSAR V1.11
caryophyllene (3%) 87-44-5 0.019  ECOSAR V1.11
lavandulol (2%) 58461-27-1 3.903  ECOSAR V1.11

using additivity formula mentionned in CLP regulation 1272/2008 in section 4.1.3.5.2., the LC50 daphnia for the lavandin oil heavy fraction is estimated at 2.92 ml/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
2.92 mg/L

Additional information

At 2.92 mg/L for EC50 daphnia 48h, the UVCB substance is classified as H411 (cat 2).

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