Reaction mass of diisopropyl hydrogen phosphate and {[hydroxy(propan-2-yloxy)phosphoryl]oxy}(propan-2-yloxy)phosphinic acid and isopropyl dihydrogen phosphate and methyl dihydrogen phosphate and phosphoric acid

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

Feb 1966

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Study design similar to OECD 401; summary report

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1966

Report date:

1966

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

7 days observation period, females tested

GLP compliance:

no

Remarks:

performed before GLP

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

(propan-2-yloxy)phosphonic acid; [(diethoxyphosphoryl)oxy](ethoxy)phosphinic acid; bis(propan-2-yloxy)phosphinic acid; methoxyphosphonic acid; phosphoric acid

EC Number:

908-995-1

Molecular formula:

can not be determined for reaction masses

IUPAC Name:

(propan-2-yloxy)phosphonic acid; [(diethoxyphosphoryl)oxy](ethoxy)phosphinic acid; bis(propan-2-yloxy)phosphinic acid; methoxyphosphonic acid; phosphoric acid

Test animals

Species:

rat

Strain:

other: Albino

Sex:

female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Fasting period before study: 12 h
- Diet (e.g. ad libitum): Standard Altromin R (Altrogge, Lage/Lippe, Germany), ad libitum
- Water (e.g. ad libitum): tap water. ad libitum

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

concentration in vehicle: 10 %

Doses:

Reinigerkomponente MI - spezial:
1.6; 2.5; 4.0 or 6.3 mL/100 g bw
corresponding to
2224;3475, 5560 or 8757 mg/kg bw (assuming a density of 1.39 g/mL of the pure substance and a 10% test solution)

No. of animals per sex per dose:

10 females/dose

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days

Statistics:

no data

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

3.75 other: mL (10% solution)/100 g bw

95% CL:

> 3.55 - <= 4

Remarks on result:

other: corresponding to: 5204 mg/kg bw

Mortality:

Dose: 1.6 mL (10% solution)/100 g, Mortality rate: 0 / 10
Dose: 2.5 mL (10% solution)/100 g, Mortality rate: 0 / 10
Dose: 4.0 mL (10% solution)/100 g, Mortality rate: 9 / 10
Dose: 6.3 mL (10% solution)/100 g, Mortality rate: 10 / 10

Clinical signs:

other: no data

Gross pathology:

no data

Other findings:

no data

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The median lethal dose of the testsubstance was 5204 mg per kg body weight. Based on the result of this study the test substance is not subject for labelling and classification requirements according to regulatory requirements.

Executive summary:

The test item was tested for its acute oral toxicity potential. 10 female rats were treated with doses of 1.6, 2.5, 4.0 or 6.3 mL (10% solution)/100 g bw and observed for 7 days.

The median lethal dose was 3.75 mL (10% solution)/100 g bw (corresponding to 5204 mg per kg body weight). Based on the result of this study the test substance is not subject for labelling and classification requirements according to regulatory requirements.