2,2'-(piperazine-1,4-diyl)bis(ethanesulphonic) acid

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2016-10-10 to 2016-10-17

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

ca. 0.58 g/L

Conc. based on:

test mat.

Loading of aqueous phase:

5 g/L

Incubation duration:

<= 3 d

Temp.:

20 °C

pH:

ca. 3

Water solubility:

ca. 0.42 g/L

Conc. based on:

test mat.

Loading of aqueous phase:

5 g/L

Incubation duration:

<= 3 d

Temp.:

10 °C

pH:

ca. 3.1

Details on results:

Water solubility standard deviation at 10 °C: 0.003
Water solubility standard deviation at 20 °C: 0.004

A preliminary test was conducted, which showed a water solubility of approx.1.0 g/L at 20 °C.

Water solubility at 20 °C:

Equilibration time	measurement 1	measurement 2	measurement 3	mean
Day 1	0.58	0.57	0.59	0.58
Day 2	0.58	0.57	0.57	0.57
Day 3	0.57	0.58	0.57	0.58
overall mean				0.58
overall standard deviation				0.004

Since the measured concentrations of Day 2 and Day 3 did not differ by more than 15 % and showed no tendency of increasing values the test results were satisfactory according to the guideline. The mean value of the measurements was calculated.

Conclusions:

The water solubility of the test item was determined at 20 °C as 0.58 g/L with a pH of 3.

Executive summary:

An experimental study was conducted according to OECD 105 and EU Regulation, Method A.6 to determine the water solubility of the test item. The preliminary test showed a water solubility of about 1 g/L at 20 °C. Therefore, the flask method was applied. The water phase was loaded with ca. 5 g/L of the test item. The concentration was determined at 3 consecutive days. The mean water solubility was determined to be 0.58 g/L at 20 °C and a pH of 3.

Description of key information

The water solubility of the test item was determined at 20 °C as 0.58 g/L with a pH of 3 (reference 4.8-1).

Key value for chemical safety assessment

Water solubility:

0.58 g/L

at the temperature of:

20 °C

Additional information

An experimental study was conducted according to OECD 105 and EU Regulation, Method A.6 to determine the water solubility of the test item. The preliminary test showed a water solubility of about 1 g/L at 20 °C. Therefore, the flask method was applied. The water phase was loaded with ca. 5 g/L of the test item. The concentration was determined at 3 consecutive days. The mean water solubility was determined to be 0.58 g/L at 20 °C and a pH of 3.