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EC number: 227-057-6 | CAS number: 5625-37-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2016-10-10 to 2016-10-17
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- ca. 0.58 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 5 g/L
- Incubation duration:
- <= 3 d
- Temp.:
- 20 °C
- pH:
- ca. 3
- Water solubility:
- ca. 0.42 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 5 g/L
- Incubation duration:
- <= 3 d
- Temp.:
- 10 °C
- pH:
- ca. 3.1
- Details on results:
- Water solubility standard deviation at 10 °C: 0.003
Water solubility standard deviation at 20 °C: 0.004
A preliminary test was conducted, which showed a water solubility of approx.1.0 g/L at 20 °C. - Conclusions:
- The water solubility of the test item was determined at 20 °C as 0.58 g/L with a pH of 3.
- Executive summary:
An experimental study was conducted according to OECD 105 and EU Regulation, Method A.6 to determine the water solubility of the test item. The preliminary test showed a water solubility of about 1 g/L at 20 °C. Therefore, the flask method was applied. The water phase was loaded with ca. 5 g/L of the test item. The concentration was determined at 3 consecutive days. The mean water solubility was determined to be 0.58 g/L at 20 °C and a pH of 3.
Reference
Water solubility at 20 °C:
| Equilibration time | measurement 1 | measurement 2 | measurement 3 | mean |
| Day 1 | 0.58 | 0.57 | 0.59 | 0.58 |
| Day 2 | 0.58 | 0.57 | 0.57 | 0.57 |
| Day 3 | 0.57 | 0.58 | 0.57 | 0.58 |
| overall mean | 0.58 | |||
| overall standard deviation | 0.004 | |||
Since the measured concentrations of Day 2 and Day 3 did not differ by more than 15 % and showed no tendency of increasing values the test results were satisfactory according to the guideline. The mean value of the measurements was calculated.
Description of key information
The water solubility of the test item was determined at 20 °C as 0.58 g/L with a pH of 3 (reference 4.8-1).
Key value for chemical safety assessment
- Water solubility:
- 0.58 g/L
- at the temperature of:
- 20 °C
Additional information
An experimental study was conducted according to OECD 105 and EU Regulation, Method A.6 to determine the water solubility of the test item. The preliminary test showed a water solubility of about 1 g/L at 20 °C. Therefore, the flask method was applied. The water phase was loaded with ca. 5 g/L of the test item. The concentration was determined at 3 consecutive days. The mean water solubility was determined to be 0.58 g/L at 20 °C and a pH of 3.
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