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EC number: 413-060-1 | CAS number: 19186-97-1
Endpoint summary
Administrative data
Description of key information
Additional information
Several studies on toxicity of FR-370 to terrestrial organisms were preformed.
In an acute toxicity study to the earthworm Eisenia fetida, earthworms were exposed for 14 days to 1000mg test substance/kg dry weight of artificial soil. Following 14 days of exposure, no mortality was observed at treatment rates up to 1000 mg/kg dw soil. LC50 was determined to be >1000 mg/kg dw soil.
In a reproductive toxicity study to the earthworm Eisenia fetida, no mortality of adult earthworms occured after 28 days of exposure up to 1000 mg/kg dry soil and no statistically significant effects upon adult earthworm weight were observed. NOEC for reproduction was determined to be 125 mg/kg dw soil. EC50 value for reproduction was detemined to be greater than 1000 mg/kg dry soil. There were statistically significant (p=0.05) effects on the numbers of juveniles produced in most of the the treatment groups. Therefore, the LOEC was determined to be 125 mg/kg and the NOEC 62.5 mg/kg dry soil.
The effects of FR-370 on seedling emergence and growth of terrestrial plants was tested first in a limit test, at test concentration of 1000mg/kg dw soil. Phytotoxic effects were noted in some of the species after seedling growing. FR-370 had no effects on the seedling emergence of tested species. However, chlorosis was caused in Beta vulgaris,Brassica napus,Cucumis sativusandPisum safivum. FR-370 was found to reduce shoot weight of Allium cepa,Avena sativaand Beta vulgaris.
Further to the effects noted in the limit test, the multiple dose-application test was conducted, using concentrations of up to 1000mg/kg. The most sensitive species was Allium cepa, with an EC50 of 55.33 mg/kg dry soil and NOEC< 0.1 mg/kg soil dw. However, the effects observed on A. cepa did not show a concentration-response curve. Actually, the precentage of inhibition at 0.1 mg/kg was comparable to that found at the highest test concentration. In addition, for some other species (i.e B.napus and P. sativum) the same precentage of inhibition was found in the carrier control. For Brassica napus, and Cucumis sativus the NOEC values for biomass (fresh weight) were 3.33 mg/kg and EC50 values were 118.96 and 132.44 respectively.
In the study of 'Nitrogen Transformation of Soil Microflora', FR-370 showed no inhibitory effects on soil microflora activity as compared to the control samples. Hence, empirically estimated EC50, on nitrate transformation is >1600 mg/kg dry soil, whereas the empirically estimated NOEC ≥1600 mg/kg dry soil.
In the study of toxicity to plants, one species out of four species tested was found to be the most sensitive species (Allium cepa).
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