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Boiling point

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Reference
Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May 23 to June 24, 2014
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Justification for type of information:
The study was conducted according to an internationally recognised method, and under GLP.
Restrictions apply considering that even if the boiling point was detected, the substance decomposes during testing and the temperature of decomposition could not be determined using SIwoloboff method. Otherwise, the substance is considered to be adequately characterised. Therefore a validation with restrictions applies.
Qualifier:
according to guideline
Guideline:
OECD Guideline 103 (Boiling point/boiling range)
Version / remarks:
dated 27. Jul. 1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.2 (Boiling Temperature)
Version / remarks:
dated 31. May 2008
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
Remarks:
inspected on 29 and 30 November 2010 / signed on 11 April 2011
Type of method:
method according to Siwoloboff
Key result
Boiling pt.:
142 °C
Atm. press.:
>= 99 981 - <= 99 991 Pa
Decomposition:
yes
Remarks:
As the test item decomposes, a correction following Sidney-Young was not applied.

Table 4.3/1: Observations

 

Determination

Boiling Point

Atmospheric Pressure

First determination

148.9 °C (422.1 K)

100196 Pa

Second determination

141.9 °C (415.1 K)

99981 Pa

Third determination

141.0 °C (414.2 K)

99991 Pa

 

The duplicate determination (experiments 1 and 2) showed a too high variation. Therefore, it was decided to perform a third determination. As the third determination confirmed the result of the second determination, determinations 2 and 3 were used for evaluation.

After cooling down, a black deposit was observed in all capillaries, which is a sign of decomposition.

 

Evaluation

As the test item decomposed, a correction following Sidney-Young was not applied.

 

Validity

As the difference between the two evaluated determinations was below 2 K, the result can be considered valid.

 

DISCUSSION

The boiling point was determined using the Siwoloboff method. After cooling down, a black deposit was observed in all capillaries. Therefore, the boiling point should be stated as 142.0 °C (415.1 K) under decomposition. These values are the means of two independent determinations. As the test item decomposes, a correction to standard pressure following Sidney-Young was not applied. No observations were made which might cause doubts on the validity of the study outcome. Therefore, the result of the study is considered valid.

Conclusions:
The boiling point was determined with 142.0 °C (415.1 K) under decomposition.
Executive summary:

A study was conduted to determine the initial boiling point of the test substance under GLP according to EU Method A.2 and OECD 103 following the SIWOLOBOFF method.

The boiling point was determined to be 142.0 °C (415.1 K) under decomposition. This value is the mean of two independent determinations. As the test item decomposes, no correction following Sidney-Young was applied.

Description of key information

The initial boiling point of the test item was determined to be 142.0 °C (415.1 K) under decomposition.

Key value for chemical safety assessment

Additional information

A reliable experimental study, conducted according to a recognized OECD/EC, following Siwoloboff method and under GLP, is available.

It is considered as a key study.

The determination was performed in triplicate and the result is the mean of two independant valid determinations. After cooling down, a black deposit was observed in all capillaries, which is a sign of decomposition. As the test item decomposes during testing, no correction following Sidney-Young was applied and no key data was retained for purpose of CSA.

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