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EC number: 946-913-6 | CAS number: -
Summary of Opacity, Permeability and In Vitro Scores
(1) Calculated using the negative control mean opacity and mean permeability values for the positive control and test item.
(2) In vitro irritancy score (IVIS) = mean opacity value + (15 x mean OD490 value).
The eye hazard potential of Copaiba balsam oil was evaluated according to OECD guideline 437 (BCOP test). The eye damage was assessed through topical application of 750 μl of the undiluted Copaiba balsam oilfor 10 minutes on top of the corneas. Both the negative control and the positive control (Ethanol) were considered valid. It was therefore concluded that the test conditions were adequate and that the test system functioned properly. Copaiba balsam oil did not induce ocular irritation (no opacity and no permeability), resulting in a mean in vitro irritancy score of -0.4 after 10 minutes of treatment.
In conclusion, since Copaiba balsam oil induced an IVIS ≤ 3, and the test substance does not need to be classified as eye irritant according to the classification criteria outlined in Annex I of 1272/2008/EC (CLP).
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