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EC number: 230-819-0 | CAS number: 7328-91-8
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
DMPDA (CAS 7328 -91 -8) is considered to be not readily biodegradable (according to OECD criteria).
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of DMPDA (CAS 7328 -91 -8) (Q)SAR results were used for aerobic biodegradability in water. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Assessment
Therefore, further experimental studies on aerobic biodegradability in water are not provided.
No experimental ready biodegradability data for DMPDA (CAS 7328 -91 -8) are available. However, the inherent biodegradability of the DMPDA was tested in an inherent Zahn-Wellens test. In this non-GLP OECD 302B test the substance proved to be not inherently biodegradable. (5% in 28 days based on DOC; BASF AG, 1987, Rep. no.: 01.494). Non-adapted activated industrial sludge was used as inoculum.
In addition, according to OECD TG 306 (Biodegradability in seawater) using natural seawater as inoculum (Eide-Haugmo et al. 2009, 2012) biodegradation of the chemical was experimentally determined to be 6.3% after 28 d (O2 -consumption) under marine conditions.
Moreover, the biodegradation potential of the substance was calculated with several Catalogic v5.11.19 estimation submodels, wich comply with the OECD principles for (Q)SAR models: CATALOGIC Kinetic (OECD 301B) v02.09; CATALOGIC Kinetic (OECD 301F) v13.16; (OECD 301C) v09.13. According these calculation models DMPDA is estimated to be not ready biodegradable. The substance was only within the AD of the submodel OECD 301C.
Based on a weight-of-evidence approach by the available experimental and calculated data, DMPDA (CAS 7328-91-8) is considered to be not readily biodegradable (according to OECD criteria).
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