Registration Dossier
Registration Dossier
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EC number: 230-819-0 | CAS number: 7328-91-8
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- according to Smyth, H.F. et al.: Am. Ind. Hyg. Ass. J. 23, 95-107 (1962)
- GLP compliance:
- no
- Test type:
- other: inhalation hazard test
Test material
- Reference substance name:
- 2,2-dimethylpropane-1,3-diamine
- EC Number:
- 230-819-0
- EC Name:
- 2,2-dimethylpropane-1,3-diamine
- Cas Number:
- 7328-91-8
- Molecular formula:
- C5H14N2
- IUPAC Name:
- 2,2-dimethylpropane-1,3-diamine
- Details on test material:
- Name of the test substance used in the study report: Neopentandiamin (= 1.3-Diamino-2,2-dimethylpropan)
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Duration of exposure:
- 7 h
- Concentrations:
- 9.41 mg/l
- No. of animals per sex per dose:
- 12
Results and discussion
- Mortality:
- none
- Clinical signs:
- other: watery eye and nasal secretion, intermittently breathing with slight breathing sounds, crusty eyes and noses, unsteady gait
- Gross pathology:
- nothing abnormal detected
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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