Registration Dossier
Registration Dossier
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EC number: 212-634-7 | CAS number: 834-12-8
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
The short-term toxicity of ametryn was evaluated in Eisenia fetida annelids in natural soil. The 7- and 14-day LC50 values were 166 mg/kg soil dw, based on mortality of the test species. The 14-day NOEC was 37 mg/kg soil dw, also based on mortality.
Eisenia fetida: LC50 (14-day) = 166 mg/kg soil dw
Eisenia fetida: LC50 (7-day) = 166 mg/kg soil dw
Eisenia fetida: NOEC (14-day) = 37 mg/kg soil dw
The CSR attached within this dossier indicates that the PNECsoil based on the equilibrium partitioning method is 0.00057 mg/kg and the regional PECsoil is 0.000000159 mg/kg dw. Thus, the PECsoil / PNECsoil ratio is less than 0.01. Therefore, according to both the general risk assessment scheme and the integrated testing strategy in Figures R.7.11-2 and R.7.11-3 of TGD 7c, no additional long-term toxicity testing for soil organisms needs to be done.
In accordance with column 2 of REACH Annex X, the long-term toxicity testing on invertebrates (required in section 9.4.4) does not need to be conducted as the chemical safety assessment according to Annex I indicates no need to investigate further the effects of the substance and/or degradation products on terrestrial organisms.
TDG 7c: Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance (November 2012; version 1.1)
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil macroorganisms:
- 166 mg/kg soil dw
Additional information
One short-term toxicity study was performed to assess the toxicity of ametryn to the soil macroorganism Eisenia fetida (Vial, 1991). The study was conducted according to OECD Guideline 207 with the following exceptions: the individual weight of the annelids ranged from 279 to 345 mg rather than 300 to 600 mg, and 48 hours of conditioning was used in lieu of 24 hours. The 14-day LC50 was reported to be 166 mg/kg with confidence limits of 129-236 mg/kg and a goodness of fit CHI of 10.1 when earthworms were exposed to G 34162 for 14 days. Values are based on nominal concentrations.
The CSR attached within this dossier indicates that the PNECsoil based on the equilibrium partitioning method is 0.00057 mg/kg and the regional PECsoil is 0.000000159 mg/kg dw. Thus, the PECsoil / PNECsoil ratio is less than 0.01. Therefore, according to both the general risk assessment scheme and the integrated testing strategy in Figures R.7.11-2 and R.7.11-3 of TGD 7c, no additional long-term toxicity testing for soil organisms needs to be done.
In accordance with column 2 of REACH Annex X, the long-term toxicity testing on invertebrates (required in section 9.4.4) does not need to be conducted as the chemical safety assessment according to Annex I indicates no need to investigate further the effects of the substance and/or degradation products on terrestrial organisms.
TDG 7c: Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance (November 2012; version 1.1)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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