Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 206-330-3 | CAS number: 328-50-7
Endpoint summary
Administrative data
Description of key information
No experimental data available/ conduct of study scientifically not necessary, please refer to the attached justification for data waiving
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vitro
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
2-oxoglutaric acid is a physiological and indispensable constituent in every living cell. It is a substrate for the tricarboxylic acid cycle and thus, modulates directly ATP generation. Although 2-oxoglutaric acid probably causes a structural alert in the most QSAR predictions, due to its fast metabolism and its ubiquitous occurrence, the initiation of sensitisation is unlikely. Therefore, and for reasons of animal welfare testing of sensitising properties is scientifically not justified. For a detailed justification please refer also to the attached justification for adaption of the registration information requirements.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on available adequate and relevant information, the test item is considered to be not a Skin sensitizer and thus does not need to be classified and labeled according Regulation (EC) No 1272/2008 (CLP) and the Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
