Registration Dossier

Administrative data

Endpoint:
skin sensitisation: in vitro
Data waiving:
other justification
Justification for data waiving:
other:
Justification for type of information:
JUSTIFICATION FOR DATA WAIVING
2-oxoglutaric acid is a physiological and indispensable constituent in every living cell. It is a substrate for the tricarboxylic acid cycle and thus, modulates directly ATP generation. Although 2-oxoglutaric acid probably causes a structural alert in the most QSAR predictions, due to its fast metabolism and its ubiquitous occurrence, the initiation of sensitisation is unlikely. Therefore, and for reasons of animal welfare testing of sensitising properties is scientifically not justified. For a detailed justification please refer also to the attached justification for adaption of the registration information requirements.

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion