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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database.

Data source

Referenceopen allclose all

Reference Type:
other: secondary source
Title:
Acute oral toxicity study of test chemical in rat
Author:
RTECS
Year:
2018
Bibliographic source:
RTECS (registry of toxic effect of chemical substance database), 2018
Reference Type:
other: authoritative database
Title:
Acute oral toxicity study of test chemical in Rat
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2018
Reference Type:
review article or handbook
Title:
Acute oral toxicity study of test chemical
Author:
Richard J. Lewis
Year:
2012
Bibliographic source:
Sax's Dangerous Properties of Industrial Materials

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute oral toxicity of test chemical in Rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
p,p',p''-tris(dimethylamino)trityl alcohol
EC Number:
207-396-6
EC Name:
p,p',p''-tris(dimethylamino)trityl alcohol
Cas Number:
467-63-0
Molecular formula:
C25H31N3O
IUPAC Name:
tris[4-(dimethylamino)phenyl]methanol
Test material form:
solid: particulate/powder
Details on test material:
IUPAC name: p,p',p''-tris(dimethylamino)trityl alcohol
Mol. formula: C25H31N3O
Molecular Weight: 389.54
Smiles: OC(c1ccc(N(C)C)cc1)(c1ccc(N(C)C)cc1)c1ccc(N(C)C)cc1
InChI: 1S/C25H31N3O/c1-26(2)22-13-7-19(8-14-22)25(29,20-9-15-23(16-10-20)27(3)4)21-11-17-24(18-12-21)28(5)6/h7-18,29H,1-6H3

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
No data
Doses:
770 mg/kg
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
No data
Statistics:
No data

Results and discussion

Preliminary study:
No data
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
770 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality observed
Mortality:
50% mortality observed at 770 mg/kg bw
Clinical signs:
other: No data
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The acute oral toxicity of test chemical in rat was observed to be 770mg/kg body weight.
Executive summary:

In acute oral toxicity study, rats were treated with test chemical at the concentration of 770mg/kg bw orally. 50% mortality observed in treated rat at 770mg/kg bw. Therefore, LD50 was considered to be 770mg/kg bw when rats were treated with test chemical orally.