Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-977-6 | CAS number: 130-15-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- 1,4-Naphthoquinone - BUA Report 211 (October 1998)
- Author:
- GDCh-Advisory Committee on Existing Chemicals (BUA)
- Year:
- 1 998
- Bibliographic source:
- S.Hirzel Verlag Stuttgart; Wissenschaftliche Verlags-Gesellschaft Stuttgart, 2000 , ISBN3-7776-1064-X
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No methods have been provided in the literature.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,4-naphthoquinone
- EC Number:
- 204-977-6
- EC Name:
- 1,4-naphthoquinone
- Cas Number:
- 130-15-4
- Molecular formula:
- C10H6O2
- IUPAC Name:
- 1,4-naphthoquinone
1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 190 mg/kg bw
- Based on:
- not specified
Any other information on results incl. tables
Male white rats (168 to 185 g) were given the substance orally as an oily solution at doses of 100, 150, 200, 250 and 300 mg/kg body weight. The LD50 was 190 (160 to 220) mg/kg body weight. In all cases postmortems revealed congestion of the internal organs, necrosis and haemorrhages of the gastric mucosa, blurring of the border between the cortex and the medulla of the kidney and in some cases "nutmeg liver" and the accumulation of gas in the small and large intestine.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- LD50= 190 mg/ kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
