1,4-naphthoquinone

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Qualifier:

no guideline available

Principles of method if other than guideline:

No guideline have been provided in the literature

GLP compliance:

not specified

Analytical monitoring:

not specified

Test organisms (species):

Cyprinus carpio

Test type:

static

Water media type:

freshwater

Hardness:

215 mg/l CaCO3

Test temperature:

25 °C

pH:

6.6

Dissolved oxygen:

4.9 mg/L

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

ca. 3 µg/L

Nominal / measured:

not specified

Conc. based on:

not specified

Basis for effect:

mortality (fish)

Sublethal observations / clinical signs:

Four carp, 2 to 6 cm in size, were introduced to each 10 -L beaker containing 5 L of different concentrations of test chemical. Five different concentrations (10, 50, 100, 200, and 500 µg /mL,

each in duplicate were prepared for each test chemical. For each test, 90% of the incubation medium was renewed with same concentration of test chemical after 48 h of incubation. Sublethal concentration (LC50) values were calculated by the trimmed Spearman-Karber method (Trimmed Spearman-Karber method for estimating median lethal concentrations in toxicity bioassays; Martin A. Hamilton, Rosemarie C. Russo, Robert V. Thurston; Environ. Sci. Technol., 1977, 11 (7), pp 714–719).

Executive summary:

The acute lethal toxicity (LC50) of 1,4-naphthoquinone has been determined to be 3 µg/l.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

3 µg/L

Additional information

The acute lethal toxicity (LC50) of1,4-naphthoquinone has been determined to be 3 µg/l.