Reaction product of D-Glucopyranoside, methyl; esterified with oleic acid, methyl ester

Endpoint summary

Additional information

Abiotic degradation

Phototransformation and hydrolysis are the main abiotic degradation pathways for a substance. Reaction product of D-Glucopyranoside, methyl; esterified with oleic acid, methyl ester (generic name: D-glucopyranoside methyl 2,6 -dioleate) is neither susceptible for phototransformation in air, water and soil nor for hydrolysis under environmental conditions. A hydrolysis study according to OECD 111 (Fox, 2015) couldn't be performed due to the low water solubility and the complexibilitx of the UVCB substance. The main functional groups within the components of the test item were ethers and esters. Ethers do not usually hydrolyze within environmentally relevant pH and temperature. Although esters can hydrolyze, especially in alkaline conditions, the test item components are considered to have a significantly reduced hydrolytic rate due to them being essentially insoluble in water. This is especially the case with the larger products that would be highly hydrophobic.

Biotic degradation

Reaction product of D-Glucopyranoside, methyl; esterified with oleic acid, methyl ester (generic name: D-glucopyranoside methyl 2,6 -dioleate) is expected to be readily biodegradable.

According to the supporting study (Clarke, 2004) the test material attained 94% degradation after 28 days. Under the strict terms and conditions of OECD Guideline No 301B the test material cannot be considered to be readily biodegradable as the test material failed to satisfy the 10-Day window validation criterion, whereby 60% degradation must be attained within 10 days of the degradation rate exceeding 10%. However, the test material has exhibited the potential for rapid degradation. The key study (Best, 2015) prooved the test item to be readily degradable. The test item attained 94% biodegradation after 28 days and satisfied the 10-Day window validation criterion, whereby 60% biodegradation must be attained within 10 days of the biodegradation exceeding 10%. The test item can therefore be considered to be readily biodegradable under the strict terms and conditions of OECD Guideline No. 301B.

Bioaccumulation

The Bioconcentration Factor (BCF) of D-glucopyranoside methyl 2,6 -dioleate was determined by calculation. This calculation was performed by the computer program from US-EPA (EPIWIN software BCFBAF v3.01). Furthermore, the whole body primary biotransformation rate estimation for fish was calculated by the same program with the notation that the bio half-life is normalized to 10 g fish at 15 °C. With this result it is possible to predict the apparent metabolism half-life in fish for three different trophic levels (lower, mid and upper). In general, the bioconcentration factor of a substance describes the accumulation potential of a substance dissolved in water by an aquatic organism.

Calculation of aquatic BCF by EPI-Win (BCFBAF, v3.01), based on measured log Pow of 6.79.

Result: BCF = 593 L/kg wet weight

The results indicates a slight potential for bioaccumulation (BCF > 500, log K_ow, but due to the high molecular weight and the low water solubility a accumulation in aquatic organisms in unlikely.

Transport and distribution

The key study (Fox, 2015) estimates the adsorbtion coefficient ot the test item to be greater than 4.27 x 10E5, log10 Koc >5.63, for more than 95% of the test item, using the HPLC screening method, designed to be compatible with Method 121 of the OECD Guidelines.

Key values for chemical safety assessment are not at 20 °C, but at 30 °C, because of the HPLC-method and the values are greater than the inscribed estimated values!

The prediction for soil adsorption property of the substance D-glucopyranoside methyl 2,6 -dioleate was determined by the computer program KOCWIN v2.00 (EPIWIN software) by US-EPA (Chemservice S.A., 2017). The program estimates the organic-normalized sorption coefficient for soil, which is designated as Koc. The following two models are used: the Salbjic molecular connectivity (MCI) method as well as the traditional method which is based on the logPow value of the substance. The MCI method is taken more seriously into account, due to the fact that is includes improved correction factors, resulting a Koc value of 4.238E6 L/kg. The traditional method gives a value of 3512 L/kg.

The prediction for the distribution between aqueous solution and air (Henry's law constant) for the substance D-glucopyranoside methyl 2,6 -dioleate was determined by the computer program HENRYWIN v3.20 (EPIWIN software) by US-EPA (Chemservice S.A., 2017). The program calculates the Henry´s Law Constant based on the Bond Method as 4.49 E-008 Pa*m³/mol at a temperature of 25 °C. The Group Method estimation resulted in an Henry´s Law Constant of 1.03E-012 Pa*m³/mol.

No GLP criteria are applicable for the usage of this tool, but due to the fact that it is a scientifically accepted calculation method the estimations performed are reliable with restrictions and can be used for the chemical safety assessment.