Reaction product of D-Glucopyranoside, methyl; esterified with oleic acid, methyl ester

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2015-04-29 - 2016-05-01

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

The department of health of the government of the United Kingdom

Type of method:

effusion method: vapour pressure balance

Key result

Temp.:

25 °C

Vapour pressure:

0.006 Pa

Temp.:

55 °C

Vapour pressure:

0.002 Pa

Temp.:

85 °C

Vapour pressure:

0.007 Pa

Preliminary Run

The recorded temperatures and mass differences, and the calculated vapor pressure values for the preliminary run are shown in the following table:

Table 1: Vapour Pressure Data from 20 to 85 °C

Temperature (°C)	Temperature (K)	Reciprocal Temperature (K-^1)	Mass Difference (µg)	Mass Difference (kg)	Vapour Pressure (Pa)	Log10Vp
20	293.15	0.003411223	8.07	8.070E-09	0.011203228	-1.950656844
24	297.15	0.003365304	13.06	1.306E-08	0.018130626	-1.741587202
25	298.15	0.003354016	7.95	7.950E-09	0.011036637	-1.957163250
29	302.15	0.003309614	8.75	8.750E-09	0.012147242	-1.915522326
33	306.15	0.003266373	3.98	3.980E-09	0.005525260	-2.257647307
43	316.15	0.003163056	4.53	4.530E-09	0.006288801	-2.201432177
53	326.15	0.003066074	7.12	7.120E-09	0.009884384	-2.005050385
57	330.15	0.003028926	8.21	8.210E-09	0.011397583	-1.943187222
61	334.15	0.002992668	10.83	1.083E-08	0.015034815	-1.822901922
62	335.15	0.002983739	11.59	1.159E-08	0.016089889	-1.793446943
63	336.15	0.002974862	12.17	1.217E-08	0.016895078	-1.772239800
64	337.15	0.002966039	12.63	1.263E-08	0.017533676	-1.756127028
65	338.15	0.002957267	14.70	1.470E-08	0.020407366	-1.690213044
66	339.15	0.002948548	14.73	1.473E-08	0.020449014	-1.689327632
67	340.15	0.002939879	15.99	1.599E-08	0.022198217	-1.653681915
68	341.15	0.002931262	16.73	1.673E-08	0.023225526	-1.634034438
69	342.15	0.002922695	17.36	1.736E-08	0.024100128	-1.617980658
70	343.15	0.002914177	18.86	1.886E-08	0.026182512	-1.581988690
71	344.15	0.002905710	19.70	1.970E-08	0.027348647	-1.563064153
72	345.15	0.002897291	21.21	2.121E-08	0.029444914	-1.530989710
73	346.15	0.002888921	21.21	2.121E-08	0.029444914	-1.530989710
74	347.15	0.002880599	22.63	2.263E-08	0.031416238	-1.502845825
75	348.15	0.002872325	24.30	2.430E-08	0.033734626	-1.471924105
76	349.15	0.002864099	26.11	2.611E-08	0.036247369	-1.440723507
77	350.15	0.002855919	28.83	2.883E-08	0.040023426	-1.397685736
78	351.15	0.002847786	28.90	2.890E-08	0.040120604	-1.396632536
79	352.15	0.002839699	31.51	3.151E-08	0.043743953	-1.359081976
80	353.15	0.002831658	34.93	3.493E-08	0.048491789	-1.314331793
81	354.15	0.002823662	36.76	3.676E-08	0.051032298	-1.292154876
82	355.15	0.002815712	38.64	3.864E-08	0.053642220	-1.270493261
83	356.15	0.002807806	40.40	4.040E-08	0.056085550	-1.251149014
84	357.15	0.002799944	45.73	4.573E-08	0.063484956	-1.197329177
85	358.15	0.002792126	48.21	4.821E-08	0.066927831	-1.174393247

Definitive Runs

The direct values of the vapor pressure at 25 °C are shown in the following table and attached graph.

Table 2: Vapour Pressure Data at 25 °C

Run	Mass Difference (µg)	Vapor Pressure (Pa)
1	4.32	0.005997267
2	4.91	0.006816338
3	4.92	0.00683022
4	4.96	0.006885751
5	4.58	0.006358213
6	4.73	0.006566452
7	4.48	0.006219388
8	3.57	0.004956075
9	4.39	0.006094445
10	4.3	0.005969502

Mean vapor pressure at 25 °C: 6.27 x 10^-3 Pa

The direct values of the vapor pressure at 55 °C are shown in the following table and attached graph.

Table 3: Vapor Pressure Data at 55 °C

Run	Mass Difference (µg)	Vapor Pressure (Pa)
1	12.52	0.017380968
2	12.14	0.01685343
3	12.45	0.01728379
4	11.19	0.015534587
5	10.73	0.014895989
6	10.39	0.014423982
7	9.59	0.013313377
8	10.17	0.014118566
9	10.06	0.013965857
10	9.81	0.013618793

Mean vapor pressure at 55 °C: 1.51x10^-2 Pa

The direct values of the vapor pressure at 85 °C are shown in the following table and graph:

Table 4: Vapor Pressure Data at 85 °C

Run	Mass Difference (µg)	Vapor Pressure (Pa)
1	52.45	0.072814038
2	56.10	0.077881173
3	55.02	0.076381856
4	52.26	0.072550269
5	52.75	0.073230514
6	50.94	0.070717771
7	50.48	0.070079173
9	49.31	0.068454913
10	49.75	0.069065746

Mean vapor pressure at 85 °C: 7.24 x 10^-2 Pa

Discussion

The determination of the vapor pressure at 55 °C and 85 °C were included at the request of the Sponsor in addition to the temperature of 25 °C specified in the guideline. The test item did not show any significant changes in its appearance under the conditions of the test.

In the 85 °C test Run 8 was not used due to a possible shutter malfunction.

Conclusion

The vapor pressure of the test item has been determined at three temperatures and the results are as follows:

Temperature (°C)	Temperature (K)	Vapor Pressure (Pa)
25	298	6.27x 10^-3Pa
55	328	1.51x 10^-2Pa
85	358	7.24x 10^-2Pa

Conclusions:

The test substance has a vapour pressure of 0,00627 Pa at 25 °C.

Executive summary:

The vapor pressure of the test item has been determined at three temperatures using the vapor pressure balance method, designed to be compatible with OECD Guideline 104 and EU Method A.4 in compliance with GLP.

A preliminary run to provide additional information was performed which covered the temperature range 20 to 85 °C in 1 °C steps. Three definitive sequences of runs were performed at 25, 55, and 85 °C with a fresh sample of test item each time. For the preliminary run the test item had been under low vacuum for approximately 40 minutes and high vacuum for approximately 17 minutes. For the definitve sequence the test item had been under low vacuum for approximately 40 minutes and high vacuum for approximately 21 minutes.

As final results, the following vapour pressures have been determined:

25 °C: 6.27 x 10^-3 Pa

55 °C: 1.51 x 10^-2 Pa

85 °C: 7.24 x 10^-2Pa

Description of key information

The vapor pressure of the test item has been determined at three temperatures using the vapor pressure balance method, designed to be compatible with OECD Guideline 104 and EU Method A.4 in compliance with GLP (Tremain, 2015).

A preliminary run to provide additional information was performed which covered the temperature range 20 to 85 °C in 1 °C steps. Three definitive sequences of runs were performed at 25, 55, and 85 °C with a fresh sample of test item each time. For the preliminary run the test item had been under low vacuum for approximately 40 minutes and high vacuum for approximately 17 minutes. For the definitve sequence the test item had been under low vacuum for approximately 40 minutes and high vacuum for approximately 21 minutes.

As final results, the following vapour pressures have been determined:

25 °C: 6.27 x 10 E-3 Pa

55 °C: 1.51 x 10E-2 Pa

85 °C: 7.24 x 10E-2 Pa

Key value for chemical safety assessment

Vapour pressure:

0.006 Pa

at the temperature of:

25 °C