Registration Dossier
Registration Dossier
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EC number: 204-898-7 | CAS number: 128-60-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: read across from simila substance
- Adequacy of study:
- weight of evidence
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- BASF internal guidelines followed
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Violanthrene-5,10-dione
- EC Number:
- 204-152-0
- EC Name:
- Violanthrene-5,10-dione
- Cas Number:
- 116-71-2
- Molecular formula:
- C34H16O2
- IUPAC Name:
- anthra[9,1,2-cde]benzo[rst]pentaphene-5,10-dione
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- 30% suspension
- Doses:
- 10000 mg/kg
- No. of animals per sex per dose:
- no data
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes - Statistics:
- NA
Results and discussion
- Preliminary study:
- NA
Effect levels
- Key result
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Remarks:
- 48% ai = LD50: 4800 mg(kg bw ai
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- no effects
- Clinical signs:
- dyspnea, hypoactivity, dark blue faeces
- Body weight:
- no data
- Gross pathology:
- no effects
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- acute oral LD50 in rats is higher than 10000 mg/kg bw based on test material, and higher than 4800 mg/kg bw based on active ingredient.
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