Registration Dossier
Registration Dossier
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EC number: 204-898-7 | CAS number: 128-60-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- in vivo
- Type of information:
- other: read across from similar substance
- Adequacy of study:
- weight of evidence
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Violanthrene-5,10-dione
- EC Number:
- 204-152-0
- EC Name:
- Violanthrene-5,10-dione
- Cas Number:
- 116-71-2
- Molecular formula:
- C34H16O2
- IUPAC Name:
- anthra[9,1,2-cde]benzo[rst]pentaphene-5,10-dione
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Himalayan
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent negative control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50 mg
- Concentration (if solution): NA - Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 8 days
- Details on study design:
- OBSERVATION TIME POINTS
1 hour, 24 hours, 8 days
SCORING SYSTEM:
- Parameters evaluated: reddening, edema, scabbing, necrosis, turbidity, scarification
- Descriptors: questionable, minimal, moderate, marked, without effect
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- test and control item
- Basis:
- mean
- Time point:
- other: 1 h/24 h/ 8 d
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- test and control item
- Basis:
- mean
- Time point:
- other: 1/24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- test and control item
- Basis:
- mean
- Time point:
- other: 8 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Remarks:
- test and control item
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Remarks:
- test and control item
- Basis:
- mean
- Time point:
- other: 14 h/8 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- other:
- Remarks:
- not irritating
- Conclusions:
- not irritating to eyes
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