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Water solubility

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Description of key information

Water solubility [1-(tert-butyldimethylsilyl)piperazine]: not relevant due to very rapid hydrolysis


Water Solubility [tert-butyldimethylsilanol]: above approximately 80 mg/l condensation reactions can occur over time, limiting the concentration dissolved in water. The calculated solubility is 970 mg/l (QSAR).


Water solubility [piperazine]: freely soluble

Key value for chemical safety assessment

Additional information

The requirement to conduct a water solubility study for the substance was waived because in contact with water, the substance hydrolyses very rapidly to form tert-butyldimethylsilanol and piperazine. The hydrolysis product, tert-butyldimethylsilanol may undergo condensation reactions in water; these become important above approximately 80 mg/l and can limit the concentration dissolved in water. For details, see the overall physicochemical properties discussion.


The water solubility of tert-butyldimethylsilanol has been calculated to be 970 mg/l at 20°C using a validated QSAR method.


Piperazine is reported to be freely soluble in water (O'Neil M J (ed) 2001).



O'Neil M J (ed.). (2001). The Merck Index-An Encyclopedia of chemicals, Drugs and Biologicals. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc. 2001. pp 1337)