Registration Dossier
Registration Dossier
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EC number: 815-305-1 | CAS number: 138938-64-4
Water solubility
Administrative data
Link to relevant study record(s)
Description of key information
Water solubility [1-(tert-butyldimethylsilyl)piperazine]: not relevant due to very rapid hydrolysis
Water Solubility [tert-butyldimethylsilanol]: above approximately 80 mg/l condensation reactions can occur over time, limiting the concentration dissolved in water. The calculated solubility is 970 mg/l (QSAR).
Water solubility [piperazine]: freely soluble
Key value for chemical safety assessment
Additional information
The requirement to conduct a water solubility study for the substance was waived because in contact with water, the substance hydrolyses very rapidly to form tert-butyldimethylsilanol and piperazine. The hydrolysis product, tert-butyldimethylsilanol may undergo condensation reactions in water; these become important above approximately 80 mg/l and can limit the concentration dissolved in water. For details, see the overall physicochemical properties discussion.
The water solubility of tert-butyldimethylsilanol has been calculated to be 970 mg/l at 20°C using a validated QSAR method.
Piperazine is reported to be freely soluble in water (O'Neil M J (ed) 2001).
Reference:
O'Neil M J (ed.). (2001). The Merck Index-An Encyclopedia of chemicals, Drugs and Biologicals. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc. 2001. pp 1337)
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