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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer - reviwed journal.

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs of 3,5,5-trimethylhexyl acetate.
Author:
D. L. J. Opdyke
Year:
1979
Bibliographic source:
Food and Cosmetics Toxicology, Page 716, 1979.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as metioned below
Principles of method if other than guideline:
Acute oral toxicity of 7-methyloctyl acetate (40379-24-6) in rats.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Isononyl acetate
EC Number:
254-898-6
EC Name:
Isononyl acetate
Cas Number:
40379-24-6
Molecular formula:
C11H22O2
IUPAC Name:
Isononyl acetate
Test material form:
liquid
Details on test material:
- Name of test material : 7-methyloctyl acetate
- Common name : Isononyl acetate
- Molecular formula : C11H22O2
- Molecular weight : 186.293 g/mol
- Smiles notation : C(C)(=O)OCCCCCCC(C)C
- InChl : 1S/C11H22O2/c1-10(2)8-6-4-5-7-9-13-11(3)12/h10H,4-9H2,1-3H3
- Substance type: Organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material : 7-methyloctyl acetate
- Common name : Isononyl acetate
- Molecular formula : C11H22O2
- Molecular weight : 186.293 g/mol
- Smiles notation : C(C)(=O)OCCCCCCC(C)C
- InChl : 1S/C11H22O2/c1-10(2)8-6-4-5-7-9-13-11(3)12/h10H,4-9H2,1-3H3
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
4250 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 250 mg/kg bw
Based on:
test mat.
95% CL:
> 3 540 - < 4 960
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed at 4250 mg/kg bw
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be 4250 mg/kg with confidential limit of 3540 - 4960 mg/kg bw when rat was treated with 7-methyloctyl acetate orally.
Executive summary:

The acute oral toxicity study was conducted by using 7-methyloctyl acetate in rat at the concentration of 4250 mg/kg. 50% morality was observed in rats at 4250 mg/kg. Hence, LD50 was considered to be 4250 mg/kg at confidential limit of 3540 - 4960 mg/kg bw, when rat was treated with 7-methyloctyl acetate orally.