Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 254-898-6 | CAS number: 40379-24-6
Endpoint summary
Administrative data
Description of key information
Biodegradation in water:
Biodegradability of 7-methyloctyl acetate (CAS no. 40379 -24 -6) is predicted using OECD QSAR toolbox version 3.4 with logKow as the primary descriptor. Test substance undergoes 90.83 % degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 7-methyloctyl acetate was estimated to be readily biodegradable in water.
Biodegradation in water and sediment: simulation tests:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 7 -methyloctyl acetate (CAS No. 40379 -24 -6). If released in to the environment, 27.3 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 7-methyloctyl acetate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of 7-methyloctyl acetate in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.368%), indicates that 7-methyloctyl acetate is not persistent in sediment.
Biodegradation in soil:
The half-life period of 7-methyloctyl acetate (CAS No.40379 -24 -6) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 65.8 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 7-methyloctyl acetate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of 7-methyloctyl acetate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low.
Additional information
Biodegradation in water:
Experimental and predicted data for the target compound 7-methyloctyl acetate (CAS no. 40379 -24 -6) and various supporting weight of evidence studies for its read across substance were reviewed for the biodegradation end point which are summarized as below:
In a prediction done by SSS (2017) using OECD QSAR toolbox version 3.4 with logKow as the primary descriptor, percentage biodegradability of test chemical 7-methyloctyl acetate was estimated. Biodegradability of 7-methyloctyl acetate (CAS no. 40379 -24 -6) is predicted. Test substance undergoes 90.83 % degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 7-methyloctyl acetate was estimated to be readily biodegradable in water.
In a prediction using the estimation Programs Interface Suite (EPI suite, 2017) was run to predict the biodegradation potential of the test compound 7-methyloctyl acetate (CAS no. 40379 -24 -6) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that the test chemical 7-methyloctyl acetate is expected to be readily biodegradable.
In a supporting weight of evidence study from peer reviewed journal (Kenneth S. Price, et. al; 1974) and authoritative database (HSDB, 2017) for the read across chemical 2-methyl propyl acetate (CAS no. 110-19-0), biodegradation experiment was conducted for 20 days for evaluating the percentage biodegradability of read across substance 2-methyl propyl acetate (CAS no. 110-19-0). Initial test substance conc. used in the study was 3, 7 and 10 mg/l, respectively. Domestic wastewater was used as a test inoculum. The BOD bottles were half filled with aerated dilution water containing the specified minerals and buffer. Small aliquots of the test chemicals were added to these bottles from 0.1% stock solutions yielding conc. of 3, 7 and 10 mg/l. At least two of these concentrations were tested in duplicate. These concentrations gave a potential oxygen demand of 3 to 30 mg/l over the 20 days duration of test. Dissolved oxygen was monitored periodically in the individual bottles through the use of a commercial DO meter filled with an agitated probe. The bottles were opened for sampling and DO measurements about five times during the course of the 20 day test. The percentage degradation of substance 2-methyl propyl acetate was determined to be 60, 74, 79 and 81% in 5, 10, 15 and 20 days, respectively. Thus, based on percentage degradation, 2-methyl propyl acetate is considered to be readily biodegradable in nature.
Another biodegradation study was conducted for 14 days for evaluating the percentage biodegradability of read across substance 3-methylbutyl 2-hydroxybenzoate (CAS no. 87-20-7) (J-CHECK, 2017 and Envichem, 2014). The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I)). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of substance 3-methylbutyl 2-hydroxybenzoate was determined to be 83.4 and 100% by BOD and GC parameter in 14 days. Thus, based on percentage degradation, 3-methylbutyl 2-hydroxybenzoate is considered to be readily biodegradable in nature.
In a supporting weight of evidence study from peer reviewed journal (A.M. Api, et. al; 2017), biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of test substance 3-Methylbutyl propanoate (CAS no. 105-68-0). The study was performed according to OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test).The percentage degradation of test substance 3-Methylbutyl propanoate was determined to be 74% by O2 consumption parameter in 28 days. Thus, based on percentage degradation, 3-Methylbutyl propanoate is considered to be readily biodegradable in nature.
On the basis of above results for target chemical 7-methyloctyl acetate (CAS no. 40379 -24 -6) (from QSAR toolbox and EPI suite, 2017) and for its read across substance (from peer reviewed journal, authoritative database J-CHECK, HSDB and Envichem, 2014), it can be concluded that the test substance 7-methyloctyl acetate can be expected to be readily biodegradable in nature.
Biodegradation in water and sediment: simulation tests:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 7 -methyloctyl acetate (CAS No. 40379 -24 -6). If released in to the environment, 27.3 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 7-methyloctyl acetate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of 7-methyloctyl acetate in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.368%), indicates that 7-methyloctyl acetate is not persistent in sediment.
Biodegradation in soil:
The half-life period of 7-methyloctyl acetate (CAS No.40379 -24 -6) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 65.8 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 7-methyloctyl acetate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of 7-methyloctyl acetate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
