Registration Dossier
Registration Dossier
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EC number: 221-816-5 | CAS number: 3244-88-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from safety assessment reports
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Methanesulfinic Acid, Aminoimino - SIDS Initial Assessment Report
- Author:
- United Nations Environmental Programme (UNEP)
- Year:
- 2 005
- Bibliographic source:
- Methanesulfinic Acid, Aminoimino - SIDS Initial Assessment Report , United Nations Environmental Programme (UNEP),2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: procedures published by the FDA (1963) and Draize and Kelley (1952).
- Principles of method if other than guideline:
- To assess the ocular irritation potential of Aminoiminomethanesulphinic acid in rabbits according to procedures published by the FDA (1963) and Draize and Kelley (1952).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Aminoiminomethanesulphinic acid
- EC Number:
- 217-157-8
- EC Name:
- Aminoiminomethanesulphinic acid
- Cas Number:
- 1758-73-2
- Molecular formula:
- CH4N2O2S
- IUPAC Name:
- Aminoiminomethanesulphinic acid
- Test material form:
- solid
- Details on test material:
- Name of the test chemical: Aminoiminomethanesulphinic acid
Molecular Formula: CH4N2O2S
Molecular Weight: 108.121 g/mol
InChI: 1S/CH4N2O2S/c2-1(3)6(4)5/h(H3,2,3)(H,4,5)
Substance Type: Organic
Physical State: Solid
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical: Aminoiminomethanesulphinic acid
Molecular Formula: CH4N2O2S
Molecular Weight: 108.121 g/mol
InChI: 1S/CH4N2O2S/c2-1(3)6(4)5/h(H3,2,3)(H,4,5)
Substance Type: Organic
Physical State: Solid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- no data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- single exposure
- Observation period (in vivo):
- 24 hours till 7 days
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- no data available
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Reversibility:
- not fully reversible within: 7 days in 4 of 6 rabbits
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- After 24 hours slight opacity of the cornea, slight iritis and moderate redness and slight to severe swelling of the conjunctivae were noted. In the course of the 7 day observation period some of these effects recovered partly or completely. However, at 7 days slight to severe cornea opacity and vascularization of the cornea were observed in 4 rabbits, ulcus cornea in 2 rabbits, slight iritis in 3 rabbits and slight lesions of the conjunctivae in all rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- After 24 hours slight opacity of the cornea, slight iritis and moderate redness and slight to severe swelling of the conjunctivae were noted. However, at 7 days slight to severe cornea opacity and vascularization of the cornea were observed in 4 rabbits, ulcus cornea in 2 rabbits, slight iritis in 3 rabbits and slight lesions of the conjunctivae in all rabbits.
Hence, Aminoiminomethanesulphinic acid can be considered to be corrosive to rabbit eyes. - Executive summary:
The ocular irritation potential of Aminoiminomethanesulphinic acid was assessed in rabbits according to procedures published by the FDA (1963) and Draize and Kelley (1952).100 mg of the test compound was instilled into everted lower lid of one eye of 6 New Zealand White rabbits. The treated eyes were observed for signs of irritation from 24 hours till 7 days.After 24 hours slight opacity of the cornea, slight iritis and moderate redness and slight to severe swelling of the conjunctivae were noted. In the course of the 7 day observation period some of these effects recovered partly or completely. However, at 7 days slight to severe cornea opacity and vascularization of the cornea were observed in 4 rabbits, ulcus cornea in 2 rabbits, slight iritis in 3 rabbits and slight lesions of the conjunctivae in all rabbits.Hence, Aminoiminomethanesulphinic acid can be considered to be corrosive to rabbit eyes.
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