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EC number: 218-129-8 | CAS number: 2051-78-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is form peer-reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Food Flavorings and Compounds of Related Structure I. Acute Oral Toxicity
- Author:
- P. M. JENNER, E C. HAGAN, JEAN M. TAYLOR, E. L. COOK and O. G. FITZHUGH
- Year:
- 1 964
- Bibliographic source:
- Fd Cosmet. Toxicol Vol. 2 pp. 327-343.
- Reference Type:
- publication
- Title:
- Fragrance Material Monograph for Allyl butyrate
- Author:
- Edited by D. L. J. Opdyke
- Year:
- 1 977
- Bibliographic source:
- Food and Cosmetics Toxicology, Volume 15, Issue 6, December 1977, Pages 613-614
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity study of Allyl butyrate in rat
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Allyl butyrate
- EC Number:
- 218-129-8
- EC Name:
- Allyl butyrate
- Cas Number:
- 2051-78-7
- Molecular formula:
- C7H12O2
- IUPAC Name:
- prop-2-en-1-yl butanoate
- Test material form:
- liquid
- Details on test material:
- - Name of test material (IUPAC name): 2-Propen-1-yl butanoate
- Common name: Allyl butyrate
- Molecular formula: C7H12O2
- Molecular weight: 128.17 g/mol
- Smiles notation: C(OCC=C)(CCC)=O
- InChl: 1S/C7H12O2/c1-3-5-7(8)9-6-4-2/h4H,2-3,5-6H2,1H3
- Substance type: Organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (IUPAC name): 2-Propen-1-yl butanoate
- Common name: Allyl butyrate
- Molecular formula: C7H12O2
- Molecular weight: 128.17 g/mol
- Smiles notation: C(OCC=C)(CCC)=O
- InChl: 1S/C7H12O2/c1-3-5-7(8)9-6-4-2/h4H,2-3,5-6H2,1H3
- Substance type: Organic
- Physical state: Liquid
Test animals
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Fasting period before study: approximately 18 hr prior to treatment.
- Diet (e.g. ad libitum): Food was replaced in cages as soon as animals received their respective doses.
- Water (e.g. ad libitum): Water, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 250 mg/kg bw
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: close observation
- Necropsy of survivors performed: No data
- Other examinations performed: Mortality, clinical signs and body weight were observed. - Statistics:
- LD50 were computed by the method of Litchfield & Wilcoxon (1949).
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 250 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 216 - 290
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- Deaths were observed between 4hr and 5 days in treated rat at 250 mg/kg bw
- Clinical signs:
- other: Depression, wet posterior and scrawny appearance for several days in treated rats.
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- LD50 was considered to be 250 mg/kg bw (216-290) when Osborne-Mendel male and female rat was treated with Allyl butyrate orally.
- Executive summary:
In a acute oral toxicity study,Osborne-Mendel male and female rat were treated with Allyl butyrate in the concentration of 250 mg/kg bw.Deaths between 4hr and 5 days were observed in treated rat at 250 mg/kg bw and Depression, wet posterior and scrawny appearance for several days in treated rats. Therefore,LD50 was considered to be 250 mg/kg bw (216-290) whenOsborne-Mendel male and femalerat was treated withAllyl butyrateorally.
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