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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May 2, 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Qualifier:
no guideline followed
Principles of method if other than guideline:
Laser Light Scattering
In order to measure the particle size distribution, the technique of laser diffraction (laser light scattering) was used by measuring the intensity of light scattered as a laser beam passes through a dispersed particulate sample. This data is then analysed to calculate the particle size distribution based on the scattering pattern.
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of distribution:
volumetric distribution
Mass median aerodynamic diameter:
25.995 µm
Key result
Percentile:
D50
Mean:
25.995 µm
Remarks on result:
other: after ultrasonic treatment (2min)
Percentile:
D10
Mean:
5.193 µm
Remarks on result:
other: after ultrasonic treatment (2min)
Percentile:
D90
Mean:
63.639 µm
Remarks on result:
other: after ultrasonic treatment (2min)

After 2 minutes of ultrasonic treatment

Conclusions:
Mass Median Diameter value is 25.995 µm.
D10 value is 5.193 µm.
D50 value is 25.995 µm.
D90 value is 63.639 µm.
Executive summary:

Method

The particle size distribution was analyzed using the Mastersizer 2000 tool, which uses the technique of laser diffraction to measure the size of particles. It does this by measuring the intensity of light scattered as a laser beam passes through a dispersed particulate sample. This data is then analyzed to calculate the size of the particles that created the scattering pattern.

Result

Analysis carried out after 2 minutes of ultrasonic treatment:

D10 value is 5.193 µm

D50 value is 25.995 µm

D90 value is 63.639 µm

Description of key information

Mass Median Diameter: 25.995 µm

Additional information

Laser light scattering method

D10 value is 5.193 µm

D50 value is 25.995 µm

D90 value is 63.639 µm