Registration Dossier
Registration Dossier
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EC number: 200-699-4 | CAS number: 68-96-2
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Predicting chemically-induced skin reactions. Part II: QSAR models of
skin permeability and the relationships between skin permeability and
skin sensitization - Author:
- Alves VM et al.
- Year:
- 2 015
- Bibliographic source:
- Toxicology and Applied Pharmacology 284 (2015) 273–280
Materials and methods
- Principles of method if other than guideline:
- In vitro human skin permeability coefficients were retrieved from the literature including 211 records expressed in logKp (cm·h−1), however, no further information on methods is available.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hydroxyprogesterone
- EC Number:
- 200-699-4
- EC Name:
- Hydroxyprogesterone
- Cas Number:
- 68-96-2
- Molecular formula:
- C21H30O3
- IUPAC Name:
- 17-hydroxypregn-4-ene-3,20-dione
Constituent 1
Results and discussion
Percutaneous absorption
- Parameter:
- other: log Kp (permeability)
- Absorption:
- -3.22 cm/h
Applicant's summary and conclusion
- Conclusions:
- The permeability coefficient log Kp of Hydroxyprogestrone is reported to be -3.22 cm/h.
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