Registration Dossier
Registration Dossier
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EC number: 289-969-0 | CAS number: 90046-02-9 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Juniperus oxycedrus, Cupressaceae.
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1988
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, but considered sufficiently reliable for the purpose of hazard assessment
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Le cade en dermatologie
- Author:
- Bouhlal K, Meynadier J, Peyron JL, Peyron L, Marion JP, Bonetti G and Meynadier J
- Year:
- 1 988
- Bibliographic source:
- Parfums, cosmétiques, arômes n°83 pp.73-82
Materials and methods
- Type of study / information:
- Skin irritation potential of Cade oil was studied in healthy volunteers.
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- Skin irritation potential of Cade oil was studied in healthy volunteers using epicutaneous tests and dermal reactions were observed.
- GLP compliance:
- no
Test material
- Reference substance name:
- Juniper, Juniperus oxycedrus, ext.
- EC Number:
- 289-969-0
- EC Name:
- Juniper, Juniperus oxycedrus, ext.
- Cas Number:
- 90046-02-9
- IUPAC Name:
- Empyreumatic oil obtained from Juniperus oxycedrus (Cupressaceae) wood by dry distillation
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Cade oil
Constituent 1
Method
- Details on study design:
- Skin irritation potential of Cade oil was studied by exposing 25 healthy volunteers at 100, 20 and 3% in petrolatum for 48h with Finn Chambers and dermal reactions were observed at 48 and 72h by two independant readers.
- Exposure assessment:
- measured
Results and discussion
- Results:
- Irritant effects were observed
Applicant's summary and conclusion
- Conclusions:
- Under the test conditions, Cade oil is considered to be irritant to skin in healthy volunteers.
- Executive summary:
In a study on 25 healthy volunteers, Cade oil was applied for 48h at 100, 20 and 3% in petrolatum using Finn chambers and dermal reactions were observed.
Irritant effects were observed.
Under the test conditions, Cade oil is considered to be irritanting to skin in healthy volunteers.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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