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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
17 March to 18 April 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an internationally recognized method, and under GLP. No deviation was reported. Test substance is adequately specified with purity. Therefore full validation applies.
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
UK GLP compliance programme (inspected on 05 July 2016 / signed on 28 October 2016)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
4.1
Temp.:
25 °C
pH:
7.2

Preliminary Estimate

The log10Pow was calculated to be: 4.4

 

Main Test

Table 4.7/1: Partition coefficient of sample

 

Injection

 

Retention time (mins)

 

Capacity factor (k′)

 

Log10k'

 

Log10Pow

 

1

4.606

2.40

0.381

4.14

2

4.592

2.39

0.379

4.13

 

Mean log10Pow: 4.1

Partition coefficient: 1.4 x 104

Conclusions:
The substance has potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log10Pow >4).
Executive summary:

The partition coefficient of the test substance was measured under GLP according to the OECD 117/EU A8 guideline, HPLC method.

The system was calibrated with 6 reference substances, and the results for the duplicate determinations of the sample were interpolated from the linear regression. The mean value, rounded for accuracy, was retained.

The partition coefficient (Pow) of the test item has been determined to be 1.4 x 104, log10Pow 4.1.

Description of key information

The substance has potential for bioaccumulation, according to CLP classification criteria for aquatic chronic toxicity (log Kow >4).

Key value for chemical safety assessment

Log Kow (Log Pow):
4.1
at the temperature of:
25 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study. The result is retained as key data for purpose of CSA.

An additional study is provided on the degradation product, for PBT and ecotoxicoloical assessment.