Registration Dossier
Registration Dossier
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EC number: 213-615-6 | CAS number: 994-30-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Chlorotriethylsilane
- EC Number:
- 213-615-6
- EC Name:
- Chlorotriethylsilane
- Cas Number:
- 994-30-9
- Molecular formula:
- C6H15ClSi
- IUPAC Name:
- chlorotriethylsilane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- CD-1
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 200 mg/kg and 2000 mg/kg
- No. of animals per sex per dose:
- 3/sex
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD100
- Effect level:
- ca. 2 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- ca. 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 2000 mg/kg b.w. resulted in the death within 5 min of all male animals.
- Clinical signs:
- other: All male animals at 2000 mg/kg body weight showed following signs of systemic toxicity: moderately reduced motility, moderate ataxia, slightly reduced muscle tonus and moderate dyspnoea immediately after administration. All animals of each sex at 200 mg/k
- Gross pathology:
- No abnormalities were found at macroscopic post mortem examination of the animals.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The oral LD50 value for Silan E3 in CD® rats was ranked within the LD50 range of 200
- 2000 mg/kg body weight. - Executive summary:
Silan E3 was administered orally by gavage to three male CD® rats at 2000 mg/kg body weight and, in addition, to six CD® rats (3 / sex) at 200 mg/kg body weight. Animals were subjected to daily observations and weekly determinations of body weight. Macroscopic examination was performed immediately after premature death or after terminal sacrifice (test day 15).
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