Registration Dossier
Registration Dossier
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EC number: 213-615-6 | CAS number: 994-30-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Chlorotriethylsilane
- EC Number:
- 213-615-6
- EC Name:
- Chlorotriethylsilane
- Cas Number:
- 994-30-9
- Molecular formula:
- C6H15ClSi
- IUPAC Name:
- chlorotriethylsilane
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- A dose of 0.5 mL of the test item was applied to the test site.
- Duration of treatment / exposure:
- Test item was held in contact with the skin throughout a 4-hour period.
- Observation period:
- The animal was euthanised immediately after patch removal.
- Number of animals:
- Due to animal welfare reason, the study was abandoned at this point and no further animal was treated.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: open wound, necrosis
- Basis:
- animal #1
- Time point:
- other: 4 h
- Remarks on result:
- other: Open wound, skin etched off, necrosis at the edges of the application side
- Irritant / corrosive response data:
- After patch removal severe clinical findings have been observed in the
animal of the initial test. The application side showed, that the skin was
etched off and that there was only an open wound left. At the edges of the
open wound the skin was already necrotic.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- Triethylchlorsilan causes severe corrosive effects.
- Executive summary:
Considering the reported data of this irritation study it can be stated that the test item Triethylchlorsilan causes severe corrosive effects. Due to severe local clinical signs at the application side of the initial animal it is non-ambiguous, that the test item does have severe irritating characteristics. Therefore no further animal was administered.
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