Registration Dossier
Registration Dossier
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EC number: 289-124-6 | CAS number: 86014-76-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Remarks:
- intraperitoneal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- - Principle of test: single intraperitoneal administration.
- Parameters analysed / observed: mortality, gross pathology. - GLP compliance:
- no
- Remarks:
- Pre 1981
Test material
- Reference substance name:
- Iron, complexes with diazotized 2-amino-4,6-dinitrophenol coupled with diazotized 4-nitrobenzenamine and 4-[(2,4-dihydroxyphenyl)azo]-5-hydroxy-2,7-naphthalenedisulfonic acid, sodium salts
- EC Number:
- 289-124-6
- EC Name:
- Iron, complexes with diazotized 2-amino-4,6-dinitrophenol coupled with diazotized 4-nitrobenzenamine and 4-[(2,4-dihydroxyphenyl)azo]-5-hydroxy-2,7-naphthalenedisulfonic acid, sodium salts
- Cas Number:
- 86014-76-8
- Molecular formula:
- n.a.
- IUPAC Name:
- Reaction products of diazotised 4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid coupled with resorcinol, subsequently coupled with diazotized 2-amino-4,6-dinitrophenol and diazotized 4-nitrobenzenamine, chelated with iron (3+), sodium salts
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 0.5 % solution
- Doses:
- 3 to 35 % suspension in vehicle
- Details on study design:
- - Observation period: 7 days.
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 423 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Deaths occurred.
- Clinical signs:
- Dyspnea, slight apathy, systemic purple-brown staining of skin, spastic gait, twitching.
- Body weight:
- Weight gain initially stagnant.
- Gross pathology:
- Intraabdominal substance deposits and adhesions.
Applicant's summary and conclusion
- Conclusions:
- LD50 (intraperitoneal) = 423 mg/kg b.w.
- Executive summary:
Mice were exposure to a single intraperitoneal administration. Clinical sings included: mortality, dyspnea, slight apathy, systemic purple-brown staining of skin, spastic gait and twitching.
Conclusion
LD50 (intraperitoneal) = 423 mg/kg b.w.
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