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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Remarks:
intraperitoneal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
- Principle of test: single intraperitoneal administration.
- Parameters analysed / observed: mortality, gross pathology.
GLP compliance:
no
Remarks:
Pre 1981

Test material

Constituent 1
Chemical structure
Reference substance name:
Iron, complexes with diazotized 2-amino-4,6-dinitrophenol coupled with diazotized 4-nitrobenzenamine and 4-[(2,4-dihydroxyphenyl)azo]-5-hydroxy-2,7-naphthalenedisulfonic acid, sodium salts
EC Number:
289-124-6
EC Name:
Iron, complexes with diazotized 2-amino-4,6-dinitrophenol coupled with diazotized 4-nitrobenzenamine and 4-[(2,4-dihydroxyphenyl)azo]-5-hydroxy-2,7-naphthalenedisulfonic acid, sodium salts
Cas Number:
86014-76-8
Molecular formula:
n.a.
IUPAC Name:
Iron, complexes with diazotized 2-amino-4,6-dinitrophenol coupled with diazotized 4-nitrobenzenamine and 4-[(2,4-dihydroxyphenyl)azo]-5-hydroxy-2,7-naphthalenedisulfonic acid, sodium salts
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test animals

Species:
mouse

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
CMC (carboxymethyl cellulose)
Remarks:
0.5 % solution
Doses:
3 to 35 % suspension in vehicle
Details on study design:
- Observation period: 7 days.

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
423 mg/kg bw
Based on:
test mat.
Mortality:
Deaths occurred.
Clinical signs:
Dyspnea, slight apathy, systemic purple-brown staining of skin, spastic gait, twitching.
Body weight:
Weight gain initially stagnant.
Gross pathology:
Intraabdominal substance deposits and adhesions.

Applicant's summary and conclusion

Conclusions:
LD50 (intraperitoneal) = 423 mg/kg b.w.
Executive summary:

Mice were exposure to a single intraperitoneal administration. Clinical sings included: mortality, dyspnea, slight apathy, systemic purple-brown staining of skin, spastic gait and twitching.

Conclusion

LD50 (intraperitoneal) = 423 mg/kg b.w.