Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
- Principle of test: single dermal application for LD50 determination.
- Parameters analysed / observed: mortality and gross pathology.
GLP compliance:
no
Remarks:
Pre 1981

Test material

Constituent 1
Chemical structure
Reference substance name:
Iron, complexes with diazotized 2-amino-4,6-dinitrophenol coupled with diazotized 4-nitrobenzenamine and 4-[(2,4-dihydroxyphenyl)azo]-5-hydroxy-2,7-naphthalenedisulfonic acid, sodium salts
EC Number:
289-124-6
EC Name:
Iron, complexes with diazotized 2-amino-4,6-dinitrophenol coupled with diazotized 4-nitrobenzenamine and 4-[(2,4-dihydroxyphenyl)azo]-5-hydroxy-2,7-naphthalenedisulfonic acid, sodium salts
Cas Number:
86014-76-8
Molecular formula:
n.a.
IUPAC Name:
Iron, complexes with diazotized 2-amino-4,6-dinitrophenol coupled with diazotized 4-nitrobenzenamine and 4-[(2,4-dihydroxyphenyl)azo]-5-hydroxy-2,7-naphthalenedisulfonic acid, sodium salts
Test material form:
solid: particulate/powder

Test animals

Species:
rat

Administration / exposure

Vehicle:
water
Remarks:
50 % preparation
Details on study design:
- Observation period: 14 days.

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 2 500 mg/kg bw
Based on:
test mat.
Mortality:
No deaths occurred.
Gross pathology:
No abnormalities observed.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
The substance was tested for acute dermal toxicity following internal guidelines. No details on study design, doses or experimental resulta are available. Howver, a qualiitative LD50> 2500 mg/kb b.w. was determined.
Executive summary:

The substance was tested for acute dermal toxicity following internal guidelines. No details on study design, doses or experimental resulta are available.Rats were exposed to a single dermal application of the test substance. After 14 days of observation, no deaths occurred and no abnormalities were noted at necropsy.

Conclusion

LD50> 2500 mg/kg b.w.