But-3-yn-2-ol

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

no data

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Comparative Developmental Toxicity of Acetylenic Alcohols on Embryos and Larvae of Xenopus laevis

Author:

Dawson D. A. et al.

Year:

1990

Bibliographic source:

Aquatic Toxicology and Risk Assessment. STP 1096. ASTM, Philadelphia, PA. 1990. p 267-277

Materials and methods

Type of study / information:

Toxicity of the test subsstance on Xenopus laevis embryo and tadpole.

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Study was performed using Xenopus laevis. An embryo test and a tadpole test were done.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

But-3-yn-2-ol

EC Number:

217-978-1

EC Name:

But-3-yn-2-ol

Cas Number:

2028-63-9

Molecular formula:

C4H6O

IUPAC Name:

but-3-yn-2-ol

Details on test material:

purity 56.1%
other component: water
according to order sheet from Dec 2nd 1988

Results and discussion

Any other information on results incl. tables

Endpoint	Effect level	Based on	Sex
Embryo LC50	0.75 mmol/L	test mat.	no data
Embryo EC50	0.71 mmol/L	test mat.	no data
Mortality/Malformation index	1.1	test mat.	no data
Tadpole LC50	0.11 mmol/L	test mat.	no data
Embryo LC50/Tadpole LC50	6.8	test mat.	no data

A linear concentration-response relationship for embryolethality, embryo malformation and 5 -day-old tadpole lethality was found. The test substance was nearly 7 times more toxic for tadpoles than embryos.