Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2019-05-10- to 2019-06-20
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
GLP compliance:
no
Type of method:
effusion method: isothermal thermogravimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine
EC Number:
811-934-0
Cas Number:
1350653-30-3
Molecular formula:
C17 H14 F2 N8
IUPAC Name:
2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine
Test material form:
solid

Results and discussion

Vapour pressure
Key result
Temp.:
20 °C
Vapour pressure:
0 Pa

Applicant's summary and conclusion

Conclusions:
The isothermal thermogravimetric effusion method was applied for the determination of the vapour pressure of Fluorotrisamine.
A value of the vapour pressure of the test item was determined using the data obtained between 260 °C and 290 °C. The vapour pressure of the test item was determined to be 0.000022 Pa at 20 °C.
Executive summary:

Title: Fluortrisamin: Determination of the Vapour Pressure by Isothermal Thermogravimetry

Guidelines / Recommendations:

This study was designed to comply with the following methods:

-European Community (EC), EC No. 761/2009, A.4: “Vapour Pressure”, 2009

-Organisation for Economic Co-operation and Development (OECD), OECD Guidelines for the Testing of Chemicals No. 104: “Vapour Pressure”, 2006

Purpose: The purpose of this study was to determine the vapour pressure of the test item using the isothermal thermogravimetrical effusion method.

Results / Conclusion: The isothermal thermogravimetrical effusion method was applied for the determination of the vapour pressure of Fluortrisamin.

A value of the vapour pressure of the test item was determined using the data obtained between 260 °C and 290 °C. The vapour pressure of the test item was determined to be 2.20 -5 Pa at 20 °C.

This study is classified acceptable and satisfies the guideline requirements for vapour pressure studies.