Registration Dossier
Registration Dossier
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EC number: 210-789-5 | CAS number: 623-36-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1950 - 54
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No guideline study. No GLP.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 954
- Reference Type:
- review article or handbook
- Title:
- no data
- Author:
- N.N.
- Year:
- 2 011
- Bibliographic source:
- Registry of Toxic effects Of Chemical Substances (RTECS) - "Prehled Prumyslove Toxikologie: Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 -,273,1986
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute eye irritation/corrosion according to Carpenter and Smyth (1946).
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methylpent-2-enal
- EC Number:
- 210-789-5
- EC Name:
- 2-methylpent-2-enal
- Cas Number:
- 623-36-9
- Molecular formula:
- C6H10O
- IUPAC Name:
- 2-methylpent-2-enal
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.005 mL
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- 5 animals (sex not specified)
- Details on study design:
- Eve injurv in rabhits records the degree of corneal necrosis from various volumes and concentrations of chemical as detailed by Carpenter and Smyth.
Grade 1 indicates at most a very small area of necrosis resulting from 0.5 mL of undiluted chemical in the eye; Grade 5 indicates a so-called severe burn from 0.005 mL and Grade 10 indicates a severe burn from 0.5 mL of a 1% solution in water or propylene glycol.
.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: corneal necrosis
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 5
- Max. score:
- 10
- Reversibility:
- not specified
- Irritant / corrosive response data:
- 2.Methyl-2-penten-1-al caused severe irritation when applied to the rabbit eye (Grade 5 on a scale of 10).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
