Registration Dossier
Registration Dossier
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EC number: 210-789-5 | CAS number: 623-36-9
Endpoint summary
Administrative data
Description of key information
Skin: The test substance was shown to lead to mild irritation on the rabbit skin(score 2/10).
Eye: In a eye irritation study with rabbits severe eye irritation was detected (score 5/10)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin:
Primary skin irritation of 2 -methyl-2 -pentene-1 -al, tested on rabbits, records in a 10-grade ordinal series the severest reaction on the clipped skin of any of five albino rabbits within 24 hours on application of 0.01 ml. of undiluted sample. Grade 1 indicates the least visible capillary injection from undiluted chemical. Grade 6 indicates necrosis when undiluted, and Grade 10 indicates necrosis from a 0.01 % solution. Test item 2 -methyl-2 -pentene-1 -al showed a primary skin irritation of 2 on a scale of 10 (Smyth, 1954).
Eye:
In a primary eye irritation study, 0.005 mL of undiluted 2 -methyl-2 -pentene-1 -al was instilled into the conjunctival sac of albino rabbits for 18-24 hours. Irritation was scored by the method of Smyth and Carpenter (1946). In the study the test substance was rated grade 5 of max. 10, corresponding to severe eye damage (Carpenter, 1946).
Effects on eye irritation: highly irritating
Justification for classification or non-classification
Based on the results obtained in skin irritation studies with rabbits the test substance has not to be classified with respect to skin irritation according to Directive 67/548/EEC (DSD) and Regulation (EC) No 1272/2008 (CLP, GHS).
Based on the results obtained in an eye irritation study with rabbits (severe eye irritation, score 5 /10) the test substance has to be classified with respect to eye irritation, Xi, R41, "Risk of serious damage to the eye" according to Directive 67/548/EEC (DSD) and with cat. 1, H318 "Causes serious eye damage" according to Regulation (EC) No 1272/2008 (CLP, GHS).
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