Dibenzo[b,f]cyclohepten-1-one

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from J-CHECK authoritative database

Qualifier:

according to guideline

Guideline:

OECD Guideline 201 (Alga, Growth Inhibition Test)

Principles of method if other than guideline:

Short term toxicity to green algae study was carried out for 72 hrs.

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material (as cited in study report): 1H-dibenzo[a,d][7]annulen-1-one
- Molecular formula (if other than submission substance): C15H10O
- Molecular weight (if other than submission substance): 206.243 g/mol
- Smiles notation (if other than submission substance): c12c(ccc3c(c1=O)cccc3)cccc2
- InChI: 1S/C15H10O/c16-15-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)15/h1-10H
- Substance type: Organic
- Physical state: Solid

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

other: green algae

Test type:

static

Water media type:

freshwater

Total exposure duration:

72 h

Nominal and measured concentrations:

Nominal concentrations

Reference substance (positive control):

not specified

Key result

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

0.14 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Key result

Duration:

72 h

Dose descriptor:

NOEC

Effect conc.:

0.011 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Key result

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

0.09 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: AUG

Key result

Duration:

72 h

Dose descriptor:

NOEC

Effect conc.:

0.022 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: AUG

Validity criteria fulfilled:

not specified

Conclusions:

Short term toxicity to green algae study was carried out for 72 hrs. according to OECD Guideline 201 (Alga, Growth Inhibition Test) for chemical 1H-dibenzo[a,d][7]annulen-1-one. The 72 hr EC50 and NOEC value was determined to be 0.14 and 0.011 mg/l, respectively based on effect on growth rate of the test organism green algae, and on the basis of AUG, the 72 hr EC50 and NOEC value was determined to be 0.09 and 0.022 mg/l, respectively.

Executive summary:

Short term toxicity to green algae study was carried out for 72 hrs. The study was performed according to OECD Guideline 201 (Alga, Growth Inhibition Test). The study was based on the effects of the test compound 1H-dibenzo[a,d][7]annulen-1-one on green algae in a static fresh water system. Based on effect on growth rate of the test organism green algae, the 72 hr EC50 and NOEC value was determined to be 0.14 and 0.011 mg/l, respectively and on the basis of AUG, the 72 hr EC50 and NOEC value was determined to be 0.09 and 0.022 mg/l, respectively. Thus, based on the EC50 value, it can be concluded that the substance 1H-dibenzo[a,d][7]annulen-1-one can be considered as toxic to aquatic organisms and thus can be classified as aquatic acute category 1 as per the CLP classification criteria.

Description of key information

Short term toxicity to green algae study was carried out for 72 hrs (J-CHECK, 2016). The study was performed according to OECD Guideline 201 (Alga, Growth Inhibition Test). The study was based on the effects of the test compound 1H-dibenzo[a,d][7]annulen-1-one on green algae in a static fresh water system. Based on effect on growth rate of the test organism green algae, the 72 hr EC50 and NOEC value was determined to be 0.14 and 0.011 mg/l, respectively and on the basis of AUG, the 72 hr EC50 and NOEC value was determined to be 0.09 and 0.022 mg/l, respectively. Thus, based on the EC50 value, it can be concluded that the substance 1H-dibenzo[a,d][7]annulen-1-one can be considered as toxic to aquatic organisms and thus can be classified as aquatic acute category 1 as per the CLP classification criteria.

Key value for chemical safety assessment

EC50 for freshwater algae:

0.14 mg/L

EC10 or NOEC for freshwater algae:

0.011 mg/L

Additional information

1 experimental key studyfor the target chemical1H-dibenzo[a,d][7]annulen-1-one (CAS no. 2222-33-5) which are supported further by total 2 studies (from authoritative database) for its closest structurally similar read across substance with logKow as the primary descriptor were reviewed for the toxicity to aquatic algae and cyanobacteria end point which are summarized as below:

 

In a key study fromauthoritative database(J-CHECK, 2016) for target chemical1H-dibenzo[a,d][7]annulen-1-one (CAS no. 2222-33-5), short term toxicity to green algae study was carried out for 72 hrs. The study was performed according to OECD Guideline 201 (Alga, Growth Inhibition Test). The study was based on the effects of the test compound 1H-dibenzo[a,d][7]annulen-1-one on green algae in a static fresh water system. Based on effect on growth rate of the test organism green algae, the 72 hr EC50 and NOEC value was determined to be 0.14 and 0.011 mg/l, respectively and on the basis of AUG, the 72 hr EC50 and NOEC value was determined to be 0.09 and 0.022 mg/l, respectively.

 

In a supporting data for read across compound Anthraquinone (CAS no. 84 -65 -1) fromauthoritative database(J-CHECK, 2016), short term toxicity to green algae study was carried out for 72 hrs. The study was based on the effects of the read across compound Anthraquinone on green algae in a static fresh water system. Based on effect on growth rate of the test organism green algae, the 72 hr EC50 and NOEC value was determined to be > 0.035 and 0.035 mg/l, respectively and on the basis of areas under the growth curves, the 72 hr EC50 and NOEC value was determined to be > 0.4 mg/l, respectively.

 

Additional supporting study for toxicity to aquatic algae and cyanobacteria for read across chemicalAnthraquinone (CAS no. 84 -65 -1)was carried out for 90 mins (ECOTOX database, 2016). The study was based on the effects of the read across compound Anthraquinone on green algae in a static fresh water system. Based on effect on physiology of the test organism algae, the EC50 value was determined to be 0.684 mg/l, respectively. 

 

Based on the overall reported results for target chemical 1H-dibenzo[a,d][7]annulen-1-one (from authoritative database J-CHECK, 2016) and for its read across substance (from J-CHECK and ECOTOX authoritative database), it can be concluded that the test substance 1H-dibenzo[a,d][7]annulen-1-one can be considered as toxic to aquatic organisms and thus can be classified as aquatic acute category 1 as per the CLP classification criteria.