Registration Dossier
Registration Dossier
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EC number: 234-324-0 | CAS number: 11099-06-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database.
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute Inhalation Toxicity - Test chemical
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- ChemIDplus
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute inhalation toxicity study of the given test chemical in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Diethoxy(dimethyl)silane
- EC Number:
- 201-127-6
- EC Name:
- Diethoxy(dimethyl)silane
- Cas Number:
- 78-62-6
- Molecular formula:
- C6H16O2Si
- IUPAC Name:
- Diethoxy(dimethyl)silane
- Details on test material:
- - IUPAC Name - Diethoxy(dimethyl)silane
- InChI - 1S/C6H16O2Si/c1-5-7-9(3,4)8-6-2/h5-6H2,1-4H3
- Smiles - [Si](OCC)(C)(OCC)C
- Molecular formula:C6H16O2Si
- Molecular weight:148.276 g/mole
- Substance type:Organ metallic
- Physical state:liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- 20000 mg/m3
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 20 000 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Mortality:
- 50% mortality observed at 20000 mg/m3 in treated animals.
- Clinical signs:
- other: not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute inhalation toxicity dose (LC50) value was considered to be 20000 mg/m3, when rats was treated with the given test chemical via inhalation route for 8 hours exposure.
- Executive summary:
Acute inhalation toxicity study was conducted in rats using the given test chemical at the dose concentration of 20000 mg/m3 via inhalation route for 8 hours exposure.
Animals were observed for mortality. 50% mortality observed at 20000 mg/m3.
Hence, the LC50 value was considered to be 20000 mg/m3, when rats was treated with the given test chemical via inhalation route for 8 hours exposure.
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