Registration Dossier
Registration Dossier
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EC number: 234-324-0 | CAS number: 11099-06-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity by using test chemical
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- ChemIDplus
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of the given test chemical in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Tetraethyl orthosilicate
- EC Number:
- 201-083-8
- EC Name:
- Tetraethyl orthosilicate
- Cas Number:
- 78-10-4
- Molecular formula:
- C8H20O4Si
- IUPAC Name:
- Tetraethyl silicate
- Details on test material:
- - IUPAC Name - Tetraethyl orthosilicate
- InChI - 1S/C8H20O4Si/c1-5-9-13(10-6-2,11-7-3)12-8-4/h5-8H2,1-4H3
- Smiles - [Si](OCC)(OCC)(OCC)OCC
- Molecular formula :C8H20O4Si
- Molecular weight :208.328 g/mole
- Substance type:Organ metallic
- Physical state:liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 6270 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 6 270 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 50% mortality observed at 6270 mg/kg bw.
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute oral LD50 value was considered to be 6270 mg/kg bw, when rats was treated with the given test chemical via oral route.
- Executive summary:
Acute oral toxicity study was conducted in rats using the given test chemical at the dose concentration of 6270 mg/kg bw.
Animals were observed for mortality. 50% mortality observed at 6270 mg/kg bw.
Hence, the LD50 value was considered to be 6270 mg/kg bw, when rats was treated with the given test chemical via oral route.
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