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EC number: 211-806-9 | CAS number: 697-82-5
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic / sediment:
From BCFBAF Program (v3.00) model of EPI suite the estimated bio concentration factor (BCF) for 2,3,5-trimethylphenol is 56.04 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.Thus it is concluded that 2,3,5-trimethylphenol is not expected to bio accumulate in fish and in the food chain.
Additional information
Bioaccumulation: aquatic / sediment:
Five studies including experimental studies and predicted data from validated models for bioaccumulation (BCF) endpoint of target chemical 2,3,5-trimethylphenol (Cas no. 697-82-5) with structurally similar read across chemical were summarized as follows:
First study from predicted model BCFBAF Program (v3.00) model which indicate the estimated bio concentration factor (BCF) for 2,3,5-trimethylphenol is 56.04 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.Thus it is concluded that 2,3,5-trimethylphenol is not expected to bio accumulate in the aquatic environment.
Other predicted database PBT profiler indicate the Bioaccumulation factor (BCF) for test substance 2,3,5-trimethylphenol was estimated to be 56 L/kg wet-wt at 25 deg.C.
And from Scifinder database suggest the Bioconcentration factor (BCF) for target chemical 2,3,5-trimethylphenol was predicted to be 90.4 at pH 1-10 and temperature 25 deg.C.
Whereas from Chemspider - ACD/PhysChem Suite it become Bioconcentration factor (BCF) for target chemical 2,3,5-trimethylphenol was estimated to be 60.00 at pH 5.5 and 7.4 at temperature 25 deg.C.
All above four predicted results are further supported by experimental data of read across chemical 2,4,6-trimethylphenol (Cas no. 527-60-6) which suggest Bioaccumulation test was conducted for 6 weeks for determination the bioconcentration factor (BCF) of substance 2,4,6-Trimethylphenol (Cas no.527-60-6) on test organism Cyprinus carpio. The recovery ratio is given- Test water : 1st concentration area : 91.8 %, 2nd concentration area : 84.5 %, Fish : 94.0 %, And Nominal concentrations used in the study as - 1st Concentration area: 0.2 ppm(w/v), 2nd Concentration area: 0.02 ppm(w/v) and Range finding study was carried out on Rice fish (Oryzias latipes) and the 48 hr LC50 value was found to be 14.3 ppm(w/v).By analytical methods, the limit of detection was found to be-
Test water : 1st concentration area : 17 ppb, 2nd concentration area : 1.9 ppb, Fish : 0.06 ppm.Thus according to static Fish Test the BCF value for test substance 2,4,6-Trimethylphenol (Cas no.527-60-6) was observed to be 6.5<=10 L/kg at dose concentration 0.2 ppm(w/v) and <= 2.7 - (8.1) L/kg at dose concentration 0.02 ppm(w/v) on test organism Cyprinus carpio during 6 weeks period. These values indicate that the substance 2,4,6-Trimethylphenol is not bioaccumulative in fish and food chain.
Thus all available studies for bioaccumulation endpoint concluded that the test substance 2,3,5-trimethylphenol (Cas no. 697-82-5) is expected to be non Bioaccumulative in aquatic environment.
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