Registration Dossier
Registration Dossier
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EC number: 205-413-1 | CAS number: 140-39-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Monographs on fragrance raw materials: p-Cresyl acetate
- Author:
- Denine
- Year:
- 1 974
- Bibliographic source:
- Food and Cosmetics Toxicology, Volume 12, Issue 3, June 1974, Pages 391
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Acute dermal toxicity study of p-tolyl acetate (CAS No. 140-39-6) in rabbits was determined.
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- p-tolyl acetate
- EC Number:
- 205-413-1
- EC Name:
- p-tolyl acetate
- Cas Number:
- 140-39-6
- Molecular formula:
- C9H10O2
- IUPAC Name:
- 4-methylphenyl acetate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (IUPAC): 4-methylphenyl acetate
- Molecular formula: C9H10O2
- Molecular weight:150.176 g/mole
- Substance type: Organic
- Physical state: Liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- No data available
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 100 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 240 - 3 570
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50 % mortality was observed in treated rabbits at 2100 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not Classified based on CLP criteria
- Conclusions:
- The acute dermal median lethal dose (LD50) of p-tolyl acetate in rabbit was observed to be 2100 mg/kg bw with 95%CL of 1244 -3570 mg/kg bw.
- Executive summary:
Acute dermal toxicity study of p-tolyl acetate (CAS No. 140-39-6) in rabbits was determined. 50 % mortality was observed in treated rabbits at 2100 mg/kg bw. Therefore, the acute dermal median lethal dose (LD50) of p-tolyl acetate in rabbit was observed to be 2100 mg/kg bw with 95%CL of 1244 -3570 mg/kg bw. Thus, according to CLP criteria for acute toxicity rating for the chemicals, it infers that p-tolyl acetate (CAS No. 140-39-6) does not classify as an acute dermal toxicant.
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