Registration Dossier
Registration Dossier
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EC number: 205-413-1 | CAS number: 140-39-6
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance material monograph for p-cresylacetate
- Author:
- D. L.J Opdyke
- Year:
- 1 974
- Bibliographic source:
- Food and Cosmetics Toxicology, Volume 12, Issue 3, June 1974, Page 391
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- other: maximization test
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- A maximization test was carried out with p-tolyl acetate on 25 human subjects.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- p-tolyl acetate
- EC Number:
- 205-413-1
- EC Name:
- p-tolyl acetate
- Cas Number:
- 140-39-6
- Molecular formula:
- C9H10O2
- IUPAC Name:
- 4-methylphenyl acetate
- Test material form:
- liquid
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 25 human subjects
- Sex: not reported
- Age: not reported
- Race: not reported
- Demographic information: not reported - Clinical history:
- No data available
- Route of administration:
- dermal
- Details on study design:
- A maximization test was carried out on 25 volunteers. The material was tested at 4% concentration in petrolatum.
Results and discussion
- Results of examinations:
- RESULT OF CASE REPORT: No sensitization reactions were observed.
Applicant's summary and conclusion
- Conclusions:
- The p-tolyl acetate (CAS No. 140-39-6) was tested at 4% concentration in petrolatum and produced no sensitisation reactions.
- Executive summary:
A maximization test was carried out on 25 volunteers. The p-tolyl acetate (CAS No. 140-39-6) was tested at 4% concentration in petrolatum and produced no sensitisation reactions. Thus, it is not classified as skin snsitizer as per CLP regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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